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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.09.004
|2 doi
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|a pubmed24n0806.xml
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|a (PII)S1521-6616(14)00215-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Nadeau, Kari C
|e verfasserin
|4 aut
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|a In utero arsenic exposure and fetal immune repertoire in a US pregnancy cohort
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 19.02.2015
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|a Date Revised 25.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Arsenic has wide-ranging effects on human health and there is evidence that it alters the immune response by influencing CD4+/CD8+ T cell ratios, IL-2 cytokine levels, and the expression of immune-response genes. We investigated the impact of in utero environmental arsenic exposure on immune development and function in newborns participating in a pregnancy cohort in New Hampshire, U.S., where arsenic levels have exceeded the current EPA maximum contaminant level of 10 μg/L. Our results showed that maternal urinary arsenic concentrations were inversely related to absolute total CD45RA+ CD4+ cord blood CD69+ T cell counts (N=116, p=0.04) and positively associated with CD45RA+ CD69- CD294+ cell counts (p=0.01). In placental samples (N=70), higher in utero urinary arsenic concentrations were positively associated with the expression of IL1β (p=0.03). These data provide evidence that relatively low-level arsenic exposure in utero may alter the fetal immune system and lead to immune dysregulation
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, U.S. Gov't, Non-P.H.S.
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|a AQP9
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|a Arsenic
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|a IL1β
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| 650 |
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|a Immune function
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|a In utero
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|a T cell
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|a Interleukin-1beta
|2 NLM
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| 650 |
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|a Arsenic
|2 NLM
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| 650 |
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|a N712M78A8G
|2 NLM
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| 700 |
1 |
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|a Li, Zhigang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Farzan, Shohreh
|e verfasserin
|4 aut
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| 700 |
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|a Koestler, Devin
|e verfasserin
|4 aut
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| 700 |
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|a Robbins, David
|e verfasserin
|4 aut
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| 700 |
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|a Fei, Dennis Liang
|e verfasserin
|4 aut
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| 700 |
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|a Malipatlolla, Meena
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Maecker, Holden
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Enelow, Richard
|e verfasserin
|4 aut
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|a Korrick, Susan
|e verfasserin
|4 aut
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| 700 |
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|a Karagas, Margaret R
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 155(2014), 2 vom: 16. Dez., Seite 188-97
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:155
|g year:2014
|g number:2
|g day:16
|g month:12
|g pages:188-97
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|u http://dx.doi.org/10.1016/j.clim.2014.09.004
|3 Volltext
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