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20250217122144.0 |
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231224s2014 xx ||||| 00| ||chi c |
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|a pubmed25n0806.xml
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|a (DE-627)NLM241928982
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|a (NLM)25224062
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Zhao, Weihong
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Comprehensive treatment of neuroblastoma in children associated with opsoclonus-myoclonus-ataxia syndrome
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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|a Band
|b nc
|2 rdacarrier
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|a Date Completed 13.01.2015
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To investigate the efficacy of combined modality therapy for neuroblastoma in children associated with opsoclonus-myoclonus syndrome (OMS-NB)
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|a METHOD: From May 2011 to December 2013, 6 consecutive patients (4 boys and 2 girls) diagnosed as OMS-NB underwent surgery and chemotherapy in the First Hospital, Peking University. The median age of onset was 19.5 months (range 13-24 months) and misdiagnosis occurred 7.5 months (range 2-14 months) ago. A retrospective analysis for the location, stage, pathological type, treatment way and outcome of neuroblastoma was done
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|a RESULT: (1) All patients were misdiagnosed as simply opsoclonus-myoclonus syndrome (OMS) at the time of onset. They had been receiving treatment with adrenocorticotropic hormone and intravenous immunoglobulin within 1-13 months.OMS-NB was diagnosed by means of enhanced abdominal CT image which was delayed to be given after the poor efficacy or relapse. (2) The primary tumors were almost all small, stage I-II, located in adrenal, retroperitoneal or pelvis. The pathology of tumors included ganglioneuroblastoma (5/6) and neuroblastoma (1/6). (3) All these cases underwent surgery, 4/6 cases with complete tumor resection, 2/6 cases with tumor around the aorta and induced local residue. Preoperative and postoperative chemotherapy was given to 2 and 5 cases, respectively. (4) The patients were followed up for 3-31 months, except 1 patient lost, the other 5 are currently surviving disease-free (3 having been at the end of chemotherapy, 1 still in chemotherapy, and another had local recurrence and is receiving radiotherapy and chemotherapy after the second operation and now also stopped taking the medicine). The symptoms of nervous system have been significantly improved during postoperative chemotherapy
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|a CONCLUSION: To reduce the misdiagnosis, regular CT imaging of the abdomen or pelvic should be ordered for all cases with OMS. The children with OMS-NB need to be actively treated with the combined modality therapy including surgery, chemotherapy or radiotherapy, to reduce recurrence and reduce the symptoms of nervous system
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|a English Abstract
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|a Journal Article
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7 |
|a Antineoplastic Agents
|2 NLM
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7 |
|a Biomarkers
|2 NLM
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| 700 |
1 |
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|a Sun, Qing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xie, Yao
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hua, Ying
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xiong, Hui
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jia, Jun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Xintian
|e verfasserin
|4 aut
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| 773 |
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8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 52(2014), 7 vom: 15. Juli, Seite 540-3
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnas
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| 773 |
1 |
8 |
|g volume:52
|g year:2014
|g number:7
|g day:15
|g month:07
|g pages:540-3
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|d 52
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|h 540-3
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