Nanocomposites of graphene and cytochrome P450 2D6 isozyme for electrochemical-driven tramadol metabolism
Cytochrome P450 enzymes (cyt P450s) with an active center of iron protoheme are involved in most clinical drugs metabolism process. Herein, an electrochemical platform for the investigation of drug metabolism in vitro was constructed by immobilizing cytochrome P450 2D6 (CYP2D6) with cyt P450 reducta...
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Détails bibliographiques
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 30(2014), 39 vom: 07. Okt., Seite 11833-40
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| Auteur principal: |
Cui, Dongmei
(Auteur) |
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| Autres auteurs: |
Mi, Li,
Xu, Xuan,
Lu, Jusheng,
Qian, Jing,
Liu, Songqin |
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| Format: | Article en ligne
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| Langue: | English |
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| Publié: |
2014
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids
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| Sujets: | Journal Article
Research Support, Non-U.S. Gov't
Cytochrome P-450 CYP2D6 Inhibitors
Enzymes, Immobilized
Isoenzymes
Tramadol
39J1LGJ30J
Graphite
7782-42-5
Polyethyleneimine
plus...
9002-98-6
Cytochrome P-450 CYP2D6
EC 1.14.14.1
Quinidine
ITX08688JL |
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