Nanocomposites of graphene and cytochrome P450 2D6 isozyme for electrochemical-driven tramadol metabolism

Cytochrome P450 enzymes (cyt P450s) with an active center of iron protoheme are involved in most clinical drugs metabolism process. Herein, an electrochemical platform for the investigation of drug metabolism in vitro was constructed by immobilizing cytochrome P450 2D6 (CYP2D6) with cyt P450 reducta...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 30(2014), 39 vom: 07. Okt., Seite 11833-40
1. Verfasser:	Cui, Dongmei (VerfasserIn)
Weitere Verfasser:	Mi, Li, Xu, Xuan, Lu, Jusheng, Qian, Jing, Liu, Songqin
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2014
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Cytochrome P-450 CYP2D6 Inhibitors Enzymes, Immobilized Isoenzymes Tramadol 39J1LGJ30J Graphite 7782-42-5 Polyethyleneimine mehr... 9002-98-6 Cytochrome P-450 CYP2D6 EC 1.14.14.1 Quinidine ITX08688JL