Microwave-assisted polyol synthesis of gadolinium-doped green luminescent carbon dots as a bimodal nanoprobe

The development of multimodal nanoprobes is highly desired in medical imaging because it integrates the advantages of multiple imaging modes. In this study, the gadolinium-doped green luminescent carbon dots (Gd-CDs) were prepared by the simple one-step microwave-assisted polyol method. The obtained...

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Veröffentlicht in:Langmuir : the ACS journal of surfaces and colloids. - 1992. - 30(2014), 36 vom: 16. Sept., Seite 10933-9
1. Verfasser: Gong, Ningqiang (VerfasserIn)
Weitere Verfasser: Wang, Hao, Li, Shuai, Deng, Yunlong, Chen, Xiao'ai, Ye, Ling, Gu, Wei
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Langmuir : the ACS journal of surfaces and colloids
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Fluorescent Dyes Polymers polyol Carbon 7440-44-0 Gadolinium AU0V1LM3JT
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520 |a The development of multimodal nanoprobes is highly desired in medical imaging because it integrates the advantages of multiple imaging modes. In this study, the gadolinium-doped green luminescent carbon dots (Gd-CDs) were prepared by the simple one-step microwave-assisted polyol method. The obtained Gd-CDs emitted a unique green photoluminescence with a quantum yield of 5.4%. The Gd-CDs exhibited a low cytotoxicity and could optically label the C6 glioma cells. Meanwhile, the r1 relaxivity of Gd-CDs was measured to be 11.356 mM(-1) s(-1). This high r1 value together with the r2/r1 ratio close to 1 nominates Gd-CDs as an excellent T1 contrast agent for magnetic resonance imaging. These Gd-CDs combining two complementary imaging modalities are therefore a promising bimodal nanoprobe in medical imaging for a better diagnosis 
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700 1 |a Wang, Hao  |e verfasserin  |4 aut 
700 1 |a Li, Shuai  |e verfasserin  |4 aut 
700 1 |a Deng, Yunlong  |e verfasserin  |4 aut 
700 1 |a Chen, Xiao'ai  |e verfasserin  |4 aut 
700 1 |a Ye, Ling  |e verfasserin  |4 aut 
700 1 |a Gu, Wei  |e verfasserin  |4 aut 
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