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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1002/adma.201402572
|2 doi
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|a pubmed24n0804.xml
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|a DE-627
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|e rakwb
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|a eng
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|a Chen, Yu
|e verfasserin
|4 aut
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|a Break-up of two-dimensional MnO2 nanosheets promotes ultrasensitive pH-triggered theranostics of cancer
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|a Date Completed 01.07.2015
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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|a Chemically exfoliated two-dimensional MnO2 nanosheets are successfully modified with amino-polyethylene glycol as a theranostic platform for ultrasensitive stimuli-responsive theranostics of cancer. The highly dispersed MnO2 nanosheets exhibit a unique break-up in the mildly acidic microenvironment of tumor tissues, which could substantially enhance their in vitro and in vivo performances in T1 -weighted magnetic resonance imaging. Such a pH-triggered breaking-up behavior could further promote the fast release of loaded anticancer drugs for concurrent pH-responsive drug release and circumvent the multidrug resistance of cancer cells
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a MnO2 nanosheets
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|a drug delivery
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|a magnetic resonance imaging
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|a nanomedicine
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|a stimuli responsive
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|a Drug Carriers
|2 NLM
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|a Manganese Compounds
|2 NLM
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|a Oxides
|2 NLM
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|a Doxorubicin
|2 NLM
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|a 80168379AG
|2 NLM
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|a manganese dioxide
|2 NLM
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|a TF219GU161
|2 NLM
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| 700 |
1 |
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|a Ye, Delai
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wu, Meiying
|e verfasserin
|4 aut
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| 700 |
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|a Chen, Hangrong
|e verfasserin
|4 aut
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| 700 |
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|a Zhang, Linlin
|e verfasserin
|4 aut
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| 700 |
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|a Shi, Jianlin
|e verfasserin
|4 aut
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| 700 |
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|a Wang, Lianzhou
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 26(2014), 41 vom: 05. Nov., Seite 7019-26
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
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| 773 |
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|g volume:26
|g year:2014
|g number:41
|g day:05
|g month:11
|g pages:7019-26
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|u http://dx.doi.org/10.1002/adma.201402572
|3 Volltext
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