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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1021/la502925p
|2 doi
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|a eng
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| 100 |
1 |
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|a Grossutti, Michael
|e verfasserin
|4 aut
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| 245 |
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|a Spectroscopic and permeation studies of phospholipid bilayers supported by a soft hydrogel scaffold
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|c 2014
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|a Text
|b txt
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|a ƒaComputermedien
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|a Date Completed 22.02.2016
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Polarized attenuated total reflection infrared (ATR-IR) spectroscopy, fluorescence microscopy, and fluorescence spectroscopy were used to characterize a lipid coating composed of 70 mol % 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and 30 mol % cholesterol, supported on a spherical hydrogel scaffold. The fluorescence microscopy images show an association between the lipid coating and the hydrogel scaffold. Fluorescence permeability measurements revealed that the phospholipid coating acts as a permeability barrier, exhibiting characteristics of a lamellar bilayer coating structure. Variable evanescent wave penetration depth ATR-IR spectroscopy studies validated the determination of quantitative molecular orientation information for a lipid coating supported on a spherical scaffold. These polarized ATR-IR studies measured an average DMPC acyl chain tilt angle of ∼21-25°, with respect to the surface normal
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Lipid Bilayers
|2 NLM
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|a Hydrogel, Polyethylene Glycol Dimethacrylate
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|a 25852-47-5
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|a Cholesterol
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|a Dimyristoylphosphatidylcholine
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| 700 |
1 |
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|a Seenath, Ryan
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|a Conlon, Shannon
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|4 aut
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|a Leitch, J Jay
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|4 aut
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|a Li, Jie
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|4 aut
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| 700 |
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|a Lipkowski, Jacek
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 30(2014), 36 vom: 16. Sept., Seite 10862-70
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|g number:36
|g day:16
|g month:09
|g pages:10862-70
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