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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1111/nph.12963
|2 doi
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|a pubmed24n0802.xml
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|a (DE-627)NLM240850742
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|a (NLM)25109749
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Das Gupta, Mainak
|e verfasserin
|4 aut
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| 245 |
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|a CINCINNATA in Antirrhinum majus directly modulates genes involved in cytokinin and auxin signaling
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 15.05.2016
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|a Date Revised 30.09.2020
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|a published: Print-Electronic
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|a GENBANK: JQ824116, JQ824117
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|a GEO: GSE40621
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|a Citation Status MEDLINE
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|a © 2014 The Authors. New Phytologist © 2014 New Phytologist Trust.
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|a Mutations in the CINCINNATA (CIN) gene in Antirrhinum majus and its orthologs in Arabidopsis result in crinkly leaves as a result of excess growth towards the leaf margin. CIN homologs code for TCP (TEOSINTE-BRANCHED 1, CYCLOIDEA, PROLIFERATING CELL FACTOR 1 AND 2) transcription factors and are expressed in a broad zone in a growing leaf distal to the proliferation zone where they accelerate cell maturation. Although a few TCP targets are known, the functional basis of CIN-mediated leaf morphogenesis remains unclear. We compared the global transcription profiles of wild-type and the cin mutant of A. majus to identify the targets of CIN. We cloned and studied the direct targets using RNA in situ hybridization, DNA-protein interaction, chromatin immunoprecipitation and reporter gene analysis. Many of the genes involved in the auxin and cytokinin signaling pathways showed altered expression in the cin mutant. Further, we showed that CIN binds to genomic regions and directly promotes the transcription of a cytokinin receptor homolog HISTIDINE KINASE 4 (AmHK4) and an IAA3/SHY2 (INDOLE-3-ACETIC ACID INDUCIBLE 3/SHORT HYPOCOTYL 2) homolog in A. majus. Our results suggest that CIN limits excess cell proliferation and maintains the flatness of the leaf surface by directly modulating the hormone pathways involved in patterning cell proliferation and differentiation during leaf growth
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Antirrhinum
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|a CINCINNATA (CIN)/TCP (TEOSINTE-BRANCHED 1, CYCLOIDEA, PROLIFERATING CELL FACTOR 1 AND 2)
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| 650 |
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|a hormone signaling
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|a leaf morphogenesis
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| 650 |
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|a transcriptional regulation
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| 650 |
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|a Cytokinins
|2 NLM
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| 650 |
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|a Indoleacetic Acids
|2 NLM
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| 650 |
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|a Plant Proteins
|2 NLM
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| 700 |
1 |
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|a Aggarwal, Pooja
|e verfasserin
|4 aut
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| 700 |
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|a Nath, Utpal
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t The New phytologist
|d 1979
|g 204(2014), 4 vom: 10. Dez., Seite 901-12
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
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| 773 |
1 |
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|g volume:204
|g year:2014
|g number:4
|g day:10
|g month:12
|g pages:901-12
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|u http://dx.doi.org/10.1111/nph.12963
|3 Volltext
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