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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4120
|2 doi
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|a pubmed24n0802.xml
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|a (DE-627)NLM240792432
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|a (NLM)25103092
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Chandran, Jima
|e verfasserin
|4 aut
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|a Molecular signal suppression by in situ microextraction in nuclear magnetic resonance spectroscopy
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 19.06.2015
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|a Date Revised 21.10.2014
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 John Wiley & Sons, Ltd.
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|a The detailed characterization of complex mixtures by NMR is often hampered by the presence of signals from uninformative compounds, the resonances of which overlap with those of the molecules of interest. We provide here a proof of principle for an approach to NMR signal suppression in complex samples using Molecularly Imprinted Polymers (MIPS). Addition of a few milligrams of polymer to a solution traps the target molecule in typical micromolar to millimolar concentration, thus achieving in situ signal suppression, without altering any other spectral features. This method minimized any manipulation or perturbation of the spectrum and was applied to a complex mixture of known compounds and to a plant extract, in both cases spiked with a compound (bisphenol A), which was subsequently removed by selective binding to a complementary MIP. What is described in this report is comparable with microextraction and may in due course be applied to a large number of analytical challenges
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Molecularly Imprinted Polymers
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|a mixture analysis
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|a nuclear magnetic resonance
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|a signal suppression
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|a Aniline Compounds
|2 NLM
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|a Benzhydryl Compounds
|2 NLM
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|a Benzyl Compounds
|2 NLM
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|a Biphenyl Compounds
|2 NLM
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|a Phenols
|2 NLM
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|a Polymers
|2 NLM
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|a diphenyl
|2 NLM
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|a 2L9GJK6MGN
|2 NLM
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|a bisphenol A
|2 NLM
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|a MLT3645I99
|2 NLM
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|a aniline
|2 NLM
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|a SIR7XX2F1K
|2 NLM
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| 700 |
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|a Shintu, Laetitia
|e verfasserin
|4 aut
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|a Caldarelli, Stefano
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 52(2014), 11 vom: 27. Nov., Seite 694-8
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
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|g volume:52
|g year:2014
|g number:11
|g day:27
|g month:11
|g pages:694-8
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|u http://dx.doi.org/10.1002/mrc.4120
|3 Volltext
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