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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.07.007
|2 doi
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|a pubmed25n0802.xml
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|a (DE-627)NLM24066759X
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|a (NLM)25088788
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|a (PII)S1521-6616(14)00188-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Millán, O
|e verfasserin
|4 aut
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| 245 |
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|a Should IFN-γ, IL-17 and IL-2 be considered predictive biomarkers of acute rejection in liver and kidney transplant? Results of a multicentric study
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 04.11.2014
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|a Date Revised 19.11.2015
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Acute rejection (AR) remains a major challenge in organ transplantation, and there is a need for predictive biomarkers. In the present multicenter study, we prospectively examined a series of biomarkers in liver and kidney recipients. Intracellular expression of IFN-γ, IL-17 and IL-2 and IL-17 soluble production were evaluated both pre-transplantation and post-transplantation (1st and 2nd week, 1st, 2nd and 3rd month). 142 transplant patients (63 liver/79 kidney) were included in the study. Twenty-eight recipients (14 liver/14 kidney) developed AR. Pre- and post-transplantation intracellular expression of %IFN-γ(+) in CD4(+)CD69(+) and in CD8(+)CD69(+) and soluble IL17 identified liver and kidney transplant patients at high risk of AR. Pre-transplantation, %IL-2(+) in CD8(+)CD69(+) also identified kidney patients at high risk. We constructed pre- and post-transplantation risk prediction models, based on a composite panel of biomarkers, which could provide the basis for future studies and will be a useful tool for the selection and adjustment of immunosuppressive treatments
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Multicenter Study
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Acute rejection;
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| 650 |
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4 |
|a Bootstrap
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| 650 |
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|a IFN-γ, IL-2 and IL-17;
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| 650 |
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4 |
|a Kidney transplantation;
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| 650 |
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|a Liver transplantation;
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| 650 |
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7 |
|a Biomarkers
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Interleukin-2
|2 NLM
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| 650 |
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7 |
|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Rafael-Valdivia, L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a San Segundo, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Boix, F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Castro-Panete, M J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a López-Hoyos, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Muro, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Valero-Hervás, D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rimola, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Navasa, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Muñoz, P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miras, M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Andrés, A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Guirado, L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pascual, J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Brunet, M
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 154(2014), 2 vom: 01. Okt., Seite 141-54
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:154
|g year:2014
|g number:2
|g day:01
|g month:10
|g pages:141-54
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2014.07.007
|3 Volltext
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 154
|j 2014
|e 2
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|h 141-54
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