|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM240461460 |
| 003 |
DE-627 |
| 005 |
20231224122144.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/adma.201402314
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0801.xml
|
| 035 |
|
|
|a (DE-627)NLM240461460
|
| 035 |
|
|
|a (NLM)25066311
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Song, Tingjie
|e verfasserin
|4 aut
|
| 245 |
1 |
3 |
|a An efficient DNA-fueled molecular machine for the discrimination of single-base changes
|
| 264 |
|
1 |
|c 2014
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 08.06.2015
|
| 500 |
|
|
|a Date Revised 30.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
|
| 520 |
|
|
|a A new strategy for single-base polymorphism (SNP) detection based on the assembly of DNA-AuNPs (gold nanoparticles) driven by a DNA-fueled molecular machine, is established and optimized. It is highly efficient, works at room temperature, and is easy to handle. A single-base change on an oligonucleotide strand is unambiguously discriminated for either SNPs or insertions and deletions (indels). The strategy is demonstrated to detect a mutation in the breast cancer gene BRCA1 in homogeneous solution at room temperature
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a DNA assembly
|
| 650 |
|
4 |
|a DNA molecular machine
|
| 650 |
|
4 |
|a gold nanoparticles
|
| 650 |
|
4 |
|a single-base change
|
| 650 |
|
4 |
|a single-base polymorphisms (SNPs)
|
| 650 |
|
7 |
|a BRCA1 Protein
|2 NLM
|
| 650 |
|
7 |
|a Gold
|2 NLM
|
| 650 |
|
7 |
|a 7440-57-5
|2 NLM
|
| 650 |
|
7 |
|a DNA
|2 NLM
|
| 650 |
|
7 |
|a 9007-49-2
|2 NLM
|
| 700 |
1 |
|
|a Xiao, Shiyan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Yao, Dongbao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Huang, Fujian
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Hu, Maobin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liang, Haojun
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Advanced materials (Deerfield Beach, Fla.)
|d 1998
|g 26(2014), 35 vom: 17. Sept., Seite 6181-5
|w (DE-627)NLM098206397
|x 1521-4095
|7 nnns
|
| 773 |
1 |
8 |
|g volume:26
|g year:2014
|g number:35
|g day:17
|g month:09
|g pages:6181-5
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/adma.201402314
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 26
|j 2014
|e 35
|b 17
|c 09
|h 6181-5
|