1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers EPC liposome, SBE-β-CD and β-CD

1H NMR studies of binary and ternary dapsone supramolecular complexes with different drug carriers : EPC liposome, SBE-β-CD and β-CD

Copyright © 2014 John Wiley & Sons, Ltd.

Bibliographische Detailangaben
Veröffentlicht in:Magnetic resonance in chemistry : MRC. - 1985. - 52(2014), 11 vom: 15. Nov., Seite 665-72
1. Verfasser: Martins, Lucas (VerfasserIn)
Weitere Verfasser: Arrais, Monica, de Souza, Alexandre, Marsaioli, Anita
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Magnetic resonance in chemistry : MRC
Schlagworte:Journal Article Research Support, Non-U.S. Gov't EPC liposome NMR SBE-β-CD dapsone β-CD Drug Carriers Macromolecular Substances Phosphatidylcholines mehr... Protons beta-Cyclodextrins SBE4-beta-cyclodextrin 2PP9364507 Dapsone 8W5C518302 betadex JV039JZZ3A
Beschreibung
Zusammenfassung:Copyright © 2014 John Wiley & Sons, Ltd.
Binary and ternary systems composed of dapsone, sulfobutylether-β-cyclodextrin (SBE-β-CD), β-CD and egg phosphatidylcholine (EPC) were evaluated using 1D ROESY, saturation transfer difference NMR and diffusion experiments (DOSY) revealing the binary complexes Dap/β-CD (K(a) 1396 l mol(-1)), Dap/SBE-β-CD (K(a) 246 l mol(-1)), Dap/EPC (K(a) 84 l mol(-1)) and the ternary complex Dap/β-CD/EPC (K(a) 18 l mol(-1)) in which dapsone is more soluble
Beschreibung:Date Completed 19.06.2015
Date Revised 16.11.2017
published: Print-Electronic
Citation Status MEDLINE
ISSN:1097-458X
DOI:10.1002/mrc.4087