Interferon alpha on NZM2328.Lc1R27 enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure

Interferon alpha on NZM2328.Lc1R27 : enhancing autoimmunity and immune complex-mediated glomerulonephritis without end stage renal failure

Copyright © 2014. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 154(2014), 1 vom: 30. Sept., Seite 66-71
1. Verfasser: Dai, Chao (VerfasserIn)
Weitere Verfasser: Wang, Hongyang, Sung, Sun-Sang J, Sharma, Rahul, Kannapell, Carol, Han, Wei, Wang, Qian, Davidson, Anne, Gaskin, Felicia, Fu, Shu Man
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Interferon α Mouse model for lupus nephritis SLE Interferon-alpha
Beschreibung
Zusammenfassung:Copyright © 2014. Published by Elsevier Inc.
Interferon alpha (IFNα) may play a significant role in systemic lupus erythematosus (SLE) pathogenesis. Recent literature suggests that IFNα does not correlate with disease activities and blockade of IFNα is not effective in treating SLE. This study aims to delineate further the role of IFNα in SLE. 12-week old NZM2328 and its congenic NZM2328.Lc1R27 (R27) female mice were challenged with adenovirus-IFNα (adeno-IFNα) or adenovirus-LacZ (adeno-LacZ). Only adeno-IFNα treated NZM2328 developed severe proteinuria and died of chronic glomerulonephritis (GN) and end stage renal disease. Adeno-IFNα treated R27 did develop immune complex-mediated GN but had normal renal function. Adeno-LacZ treated NZM2328 showed enlarged glomeruli and increased cellularity without immune complex deposition. Adeno-LacZ treated R27 did not show serological and histological abnormalities. Adeno-IFNα induced anti-dsDNA and anti-kidney autoantibodies in NZM2328 and R27. These results suggest that end organ damage is host-dependent and less related to autoimmunity and may have significant implications in SLE pathogenesis
Beschreibung:Date Completed 30.09.2014
Date Revised 21.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.06.008