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cr uuu---uuuuu |
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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.06.007
|2 doi
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|a pubmed24n1435.xml
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|a (DE-627)NLM239589521
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|a (NLM)24971701
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|a (PII)S1521-6616(14)00154-5
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Pawar, Rahul D
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Serum autoantibodies in pristane induced lupus are regulated by neutrophil gelatinase associated lipocalin
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 30.09.2014
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|a Date Revised 10.06.2024
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a The onset of autoantibodies in systemic autoimmunity can be the result of a breakdown in tolerance at multiple checkpoints. Genetic, hormonal, and immunological factors can combine with environmental influences to accelerate the onset of disease and aggravate disease outcome. Here, we describe a novel mechanism relating to the regulatory role of Neutrophil Gelatinase Associated Lipocalin (NGAL) in modulating the levels of autoantibodies in pristane induced lupus. Following a single injection of pristane intraperitoneally, NGAL expression was induced in both the serum and spleen. Furthermore, NGAL deficient mice were more susceptible to the induction of pristane stimulated autoimmunity, and displayed higher numbers of autoantibody secreting cells and increased expression of activation induced cytidine deaminase (AID) and other inflammatory mediators in the spleen. In contrast, kidney damage was milder in NGAL deficient mice, indicating that NGAL was detrimental in autoantibody mediated kidney disease. These studies indicate that NGAL plays differential roles in different tissues in the context of lupus, and suggest a previously unrecognized role for NGAL in adaptive immunity
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Autoantibodies
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4 |
|a Lipocalin-2
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| 650 |
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4 |
|a NGAL
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| 650 |
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4 |
|a Pristane
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| 650 |
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4 |
|a SLE
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| 650 |
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|a Acute-Phase Proteins
|2 NLM
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| 650 |
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7 |
|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a LCN2 protein, human
|2 NLM
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| 650 |
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|a Lipocalin-2
|2 NLM
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| 650 |
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7 |
|a Lipocalins
|2 NLM
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| 650 |
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7 |
|a Proto-Oncogene Proteins
|2 NLM
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| 650 |
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7 |
|a Terpenes
|2 NLM
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| 650 |
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|a Interleukin-12
|2 NLM
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| 650 |
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7 |
|a 187348-17-0
|2 NLM
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| 650 |
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7 |
|a pristane
|2 NLM
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| 650 |
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7 |
|a 26HZV48DT1
|2 NLM
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| 700 |
1 |
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|a Goilav, Beatrice
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xia, Yumin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhuang, Haoyang
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Herlitz, Leal
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Reeves, Westley H
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Putterman, Chaim
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 154(2014), 1 vom: 15. Sept., Seite 49-65
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:154
|g year:2014
|g number:1
|g day:15
|g month:09
|g pages:49-65
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2014.06.007
|3 Volltext
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|a AR
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|d 154
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|h 49-65
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