Interaction of a biguanide compound with membrane model interface systems : probing the properties of antimalaria and antidiabetic compounds

Since membrane penetration is important for drug efficacy, how antimalarial precursor material 1-phenylbiguanide (PBG) interacts with an interface was characterized using a reverse micelle (RM) model system. (1)H NMR studies show that PBG partitions across the membrane interface. Specifically, the (...

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Publié dans:	Langmuir : the ACS journal of surfaces and colloids. - 1985. - 30(2014), 29 vom: 29. Juli, Seite 8697-706
Auteur principal:	Samart, Nuttaporn (Auteur)
Autres auteurs:	Beuning, Cheryle N, Haller, Kenneth J, Rithner, Chris D, Crans, Debbie C
Format:	Article en ligne
Langue:	English
Publié:	2014
Accès à la collection:	Langmuir : the ACS journal of surfaces and colloids
Sujets:	Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Antimalarials Biguanides Hypoglycemic Agents Membranes, Artificial Micelles Prodrugs Protons plus... Water 059QF0KO0R phenyl biguanide W8PKA3T2I3