The lectin pathway of complement : advantage or disadvantage in HIV pathogenesis?

Copyright © 2014 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 154(2014), 1 vom: 28. Sept., Seite 13-25
1. Verfasser: Ballegaard, V (VerfasserIn)
Weitere Verfasser: Haugaard, A K, Garred, P, Nielsen, S D, Munthe-Fog, L
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Review Collectin-11 Ficolin-1, -2 and -3 HIV Innate immunity Lectin pathway Mannose-binding lectin (MBL)
Beschreibung
Zusammenfassung:Copyright © 2014 Elsevier Inc. All rights reserved.
The pattern recognition molecules of the lectin complement pathway are important components of the innate immune system with known functions in host-virus interactions. This paper summarizes current knowledge of how these intriguing molecules, including mannose-binding lectin (MBL), Ficolin-1, -2 and -3, and collectin-11 (CL-11) may influence HIV-pathogenesis. It has been demonstrated that MBL is capable of binding and neutralizing HIV and may affect host susceptibility to HIV infection and disease progression. In addition, MBL may cause variations in the host immune response against HIV. Ficolin-1, -2 and -3 and CL-11 could have similar functions in HIV infection as the ficolins have been shown to play a role in other viral infections, and CL-11 resembles MBL and the ficolins in structure and binding capacity
Beschreibung:Date Completed 30.09.2014
Date Revised 02.08.2014
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.06.002