Off-on polyadenylation strategy as a supplemental mechanism for silencing toxic transgene expression during lentiviral vector production

Many gene therapy strategies rely on lentiviral-mediated transfer and expression of genes coding for toxic proteins. Methods of controlling transgene expression in target cells have been extensively investigated, but comparatively little attention has been given to controlling toxic protein expressi...

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Veröffentlicht in:	BioTechniques. - 1991. - 56(2014), 6 vom: 13. Juni, Seite 311-2, 314-8
1. Verfasser:	Bagnis, Claude (VerfasserIn)
Weitere Verfasser:	Zwojsczyki, Gael, Chiaroni, Jacques, Bailly, Pascal
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2014
Zugriff auf das übergeordnete Werk:	BioTechniques
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't lentiviral vector polyadenylation production toxic transgenes RNA, Messenger enhanced green fluorescent protein Green Fluorescent Proteins 147336-22-9