|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM238882519 |
| 003 |
DE-627 |
| 005 |
20231224114738.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1111/nph.12867
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0796.xml
|
| 035 |
|
|
|a (DE-627)NLM238882519
|
| 035 |
|
|
|a (NLM)24897938
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Konrad, Sebastian S A
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a S-acylation anchors remorin proteins to the plasma membrane but does not primarily determine their localization in membrane microdomains
|
| 264 |
|
1 |
|c 2014
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 30.03.2015
|
| 500 |
|
|
|a Date Revised 30.09.2020
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a GENBANK: AEX20500
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a © 2014 The Authors. New Phytologist © 2014 New Phytologist Trust.
|
| 520 |
|
|
|a Remorins are well-established marker proteins for plasma membrane microdomains. They specifically localize to the inner membrane leaflet despite an overall hydrophilic amino acid composition. Here, we determined amino acids and post-translational lipidations that are required for membrane association of remorin proteins. We used a combination of cell biological and biochemical approaches to localize remorin proteins and truncated variants of those in living cells and determined S-acylation on defined residues in these proteins. S-acylation of cysteine residues in a C-terminal hydrophobic core contributes to membrane association of most remorin proteins. While S-acylation patterns differ between members of this multi-gene family, initial membrane association is mediated by protein-protein or protein-lipid interactions. However, S-acylation is not a key determinant for the localization of remorins in membrane microdomains. Although remorins bind via a conserved mechanism to the plasma membrane, other membrane-resident proteins may be involved in the recruitment of remorins into membrane domains. S-acylation probably occurs after an initial targeting of the proteins to the plasma membrane and locks remorins in this compartment. As S-acylation is a reversible post-translational modification, stimulus-dependent intracellular trafficking of these proteins can be envisioned
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a S-acylation
|
| 650 |
|
4 |
|a membrane domain
|
| 650 |
|
4 |
|a palmitoylation
|
| 650 |
|
4 |
|a protein-protein interaction
|
| 650 |
|
4 |
|a remorin
|
| 650 |
|
7 |
|a Carrier Proteins
|2 NLM
|
| 650 |
|
7 |
|a Peptides
|2 NLM
|
| 650 |
|
7 |
|a Phosphoproteins
|2 NLM
|
| 650 |
|
7 |
|a Plant Proteins
|2 NLM
|
| 650 |
|
7 |
|a Sterols
|2 NLM
|
| 650 |
|
7 |
|a remorin
|2 NLM
|
| 650 |
|
7 |
|a Cysteine
|2 NLM
|
| 650 |
|
7 |
|a K848JZ4886
|2 NLM
|
| 700 |
1 |
|
|a Popp, Claudia
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Stratil, Thomas F
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Jarsch, Iris K
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Thallmair, Veronika
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Folgmann, Jessica
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Marín, Macarena
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Ott, Thomas
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t The New phytologist
|d 1979
|g 203(2014), 3 vom: 05. Aug., Seite 758-69
|w (DE-627)NLM09818248X
|x 1469-8137
|7 nnns
|
| 773 |
1 |
8 |
|g volume:203
|g year:2014
|g number:3
|g day:05
|g month:08
|g pages:758-69
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1111/nph.12867
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 203
|j 2014
|e 3
|b 05
|c 08
|h 758-69
|