The safety and efficacy of sunitinib using a modified regimen (2 weeks on/1 week off) for treatment of metastatic renal cell carcinoma

The safety and efficacy of sunitinib using a modified regimen (2 weeks on/1 week off) for treatment of metastatic renal cell carcinoma

We prospectively investigated the safety and efficacy of sunitinib using a modified regimen (2 weeks on/1 week off) in 24 patients (22 males, 2 females ; age range 39-86 years, median 64 years) with metastatic renal cell carcinoma (RCC). During the observation period (3-62 weeks, median 21 weeks), t...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 60(2014), 5 vom: 01. Mai, Seite 209-14
1. Verfasser: Togo, Yoshikazu (VerfasserIn)
Weitere Verfasser: Shimatani, Kimihiro, Hanasaki, Tsuyoshi, Yo, Toeki, Nakanishi, Yukako, Nagasawa, Seiji, Hashimoto, Takahiko, Shiraishi, Yusuke, Taoka, Rikiya, Suzuki, Toru, Go, Shuken, Higuchi, Yoshihide, Kanematsu, Akihiro, Nojima, Michio, Tsuchihashi, Kazunari, Makino, Yuki, Shimizu, Yosuke, Kanamaru, Sojun, Kono, Yuka, Matsumoto, Keiyu, Utsunomiya, Noriaki, Ito, Noriyuki, Kawakita, Mutsushi, Yamamoto, Shingo
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Journal Article Antineoplastic Agents Indoles Pyrroles Sunitinib V99T50803M
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520 |a We prospectively investigated the safety and efficacy of sunitinib using a modified regimen (2 weeks on/1 week off) in 24 patients (22 males, 2 females ; age range 39-86 years, median 64 years) with metastatic renal cell carcinoma (RCC). During the observation period (3-62 weeks, median 21 weeks), thrombocytopenia was seen in 13 (54.2%), leukopenia in 11 (45.8%), hand-foot syndrome in 5 (20.8%), hypertension in 4 (16.7%), and hypothyroidism in 3 (12.5%) patients, while grade 3 or higher adverse events were found in 4 (16.7%), 1 (4.2%), 1 (4.2%), 2 (8.3%), and 0 patients, respectively. Of the 21 patients evaluable for response, 5 (23. 8%) showed partial response, 8 (38.1%) stable disease, and 8 (38.1%) progressive disease. This new modified regimen may lead to a reduction in adverse events for treatment of patients with metastatic RCC as a substitute for the standard dosing regimen of sunitinib 
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700 1 |a Nakanishi, Yukako  |e verfasserin  |4 aut 
700 1 |a Nagasawa, Seiji  |e verfasserin  |4 aut 
700 1 |a Hashimoto, Takahiko  |e verfasserin  |4 aut 
700 1 |a Shiraishi, Yusuke  |e verfasserin  |4 aut 
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700 1 |a Shimizu, Yosuke  |e verfasserin  |4 aut 
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700 1 |a Ito, Noriyuki  |e verfasserin  |4 aut 
700 1 |a Kawakita, Mutsushi  |e verfasserin  |4 aut 
700 1 |a Yamamoto, Shingo  |e verfasserin  |4 aut 
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