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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.05.006
|2 doi
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|a pubmed25n0795.xml
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|a (DE-627)NLM238532771
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|a (NLM)24858581
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Jones, Carmen Baca
|e verfasserin
|4 aut
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| 245 |
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|a Regulatory T cells control diabetes without compromising acute anti-viral defense
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 05.09.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a While previous reports have demonstrated the efficacy of regulatory T cell therapy in the prevention of diabetes, systemic immunocompromise and Treg instability remain key safety concerns. Here we examined the influence of induced Treg (iTreg) cell therapy on anti-viral host defense and autoimmune T cell responses during acute viral infection in a murine model of autoimmune diabetes. Protective transfers of iTregs maintained IL-10 expression, expanded in vivo and controlled diabetes, despite losing FoxP3 expression. Adoptive transfer of iTregs affected neither the primary anti-viral CD8 T cell response nor viral clearance, although a significant and sustained suppression of CD4 T cell responses was observed. Following acute viral clearance, iTregs transferred early suppressed both CD4 and CD8 T cell responses, which resulted in the reversion of diabetes. These observations indicate that iTregs suppress local autoimmune processes while preserving the immunocompetent host's ability to combat acute viral infection
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Diabetes;
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|a Regulatory T cells;
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| 650 |
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|a Safety;
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| 650 |
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|a Stability;
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| 650 |
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4 |
|a Therapy
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| 650 |
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4 |
|a Viral infection;
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| 650 |
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|a Forkhead Transcription Factors
|2 NLM
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| 650 |
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|a Foxp3 protein, mouse
|2 NLM
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| 650 |
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|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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7 |
|a 130068-27-8
|2 NLM
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| 650 |
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|a Green Fluorescent Proteins
|2 NLM
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| 650 |
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7 |
|a 147336-22-9
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Pagni, Philippe P
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fousteri, Georgia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sachithanantham, Sowbarnika
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Dave, Amy
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rodriguez-Calvo, Teresa
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Miller, Jacqueline
|e verfasserin
|4 aut
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| 700 |
1 |
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|a von Herrath, Matthias
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 2 vom: 20. Aug., Seite 298-307
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:153
|g year:2014
|g number:2
|g day:20
|g month:08
|g pages:298-307
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2014.05.006
|3 Volltext
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