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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.05.005
|2 doi
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|a pubmed24n0795.xml
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|a (DE-627)NLM238529665
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|a (NLM)24858261
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|a (PII)S1521-6616(14)00132-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Yang, Neng
|e verfasserin
|4 aut
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| 245 |
1 |
2 |
|a A Trichosanthin-derived peptide suppresses type 1 immune responses by TLR2-dependent activation of CD8(+)CD28(-) Tregs
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 05.09.2014
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|a Date Revised 16.11.2017
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a A group of 15-aa-long Trichosanthin-derived peptides was synthesized and screened based on their differential abilities to induce low-responsiveness in mouse strains with high and low susceptibility. One of them was conjugated to form a homo-tetramer Tk-tPN. At concentrations of 0.1-50 μg/ml, Tk-tPN activated CD8(+)CD28(-) Tregs in vitro to induce immune suppression as effectively as the native Trichosanthin but did not exhibit cytotoxicity. In EAE mice which were pre-treated with Tk-tPN or Tk-tPN-activated CD8(+) T cells, a marked attenuation of clinical scores was recorded together with an expansion of the CD8(+)CD28(-) Treg from 2.2% to 36.1% in vivo. A pull-down assay and signal transduction analyses indicated that the ability of Tk-tPN to convert the CD8(+)CD28(-) Treg-related cytokine secretion pattern from type 1 to type 2 depends on the TLR2-initiated signaling in macrophages. The high production of IL-4/IL-10 by the Tk-tPN-activated CD8(+)CD28(-) Treg suggests the value of using Tk-tPN as a therapeutic reagent for Th1-dominant immunological diseases
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a CD8(+)CD28(−) Treg
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|a EAE
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|a TLR2 signaling
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|a Trichosanthin-derived peptide
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|a CD28 Antigens
|2 NLM
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|a CD8 Antigens
|2 NLM
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| 650 |
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|a Peptides
|2 NLM
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|a Tlr2 protein, mouse
|2 NLM
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| 650 |
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|a Toll-Like Receptor 2
|2 NLM
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| 650 |
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|a Interleukin-10
|2 NLM
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| 650 |
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|a 130068-27-8
|2 NLM
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| 650 |
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|a Interleukin-4
|2 NLM
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| 650 |
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|a 207137-56-2
|2 NLM
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| 650 |
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|a Trichosanthin
|2 NLM
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| 650 |
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|a 60318-52-7
|2 NLM
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| 700 |
1 |
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|a Li, Zuoqing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Jiao, Zhijun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Gu, Peng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zhou, Yun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lu, Liming
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chou, Kuang-Yen
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 2 vom: 15. Aug., Seite 277-87
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:153
|g year:2014
|g number:2
|g day:15
|g month:08
|g pages:277-87
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2014.05.005
|3 Volltext
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|a AR
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|d 153
|j 2014
|e 2
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|h 277-87
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