Self-assembly of polyisoprenoyl gemcitabine conjugates : influence of supramolecular organization on their biological activity
An amphiphilic prodrug of gemcitabine, a cytidine analogue used clinically against various tumors, had been previously synthesized by covalent coupling to squalene, a natural isoprenoid chain. The resulting bioconjugate self-assembled spontaneously in water as nanoparticles, displaying an impressive...
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Détails bibliographiques
| Publié dans: | Langmuir : the ACS journal of surfaces and colloids. - 1985. - 30(2014), 22 vom: 10. Juni, Seite 6348-57
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| Auteur principal: |
Lepeltier, Elise
(Auteur) |
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| Autres auteurs: |
Bourgaux, Claudie,
Maksimenko, Andrey,
Meneau, Florian,
Rosilio, Véronique,
Sliwinski, Eric,
Zouhiri, Fatima,
Desmaële, Didier,
Couvreur, Patrick |
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| Format: | Article en ligne
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| Langue: | English |
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| Publié: |
2014
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| Accès à la collection: | Langmuir : the ACS journal of surfaces and colloids
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| Sujets: | Journal Article
Research Support, Non-U.S. Gov't
Antineoplastic Agents
Deoxycytidine
0W860991D6
Squalene
7QWM220FJH
Gemcitabine |
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