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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1021/la501296r
|2 doi
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|a pubmed24n0794.xml
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|a (NLM)24826785
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Su, Cuicui
|e verfasserin
|4 aut
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|a Liposomes physically coated with peptides
|b preparation and characterization
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 11.05.2015
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|a Date Revised 03.06.2014
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Physically coating liposomes with peptides of desirable functions is an economic, versatile, and less time-consuming approach to prepare drug delivery vehicles. In this work, we designed three peptides-Ac-WWKKKGGNNN-NH2 (W2K3), Ac-WWRRRGGNNN-NH2(W2R3), Ac-WWGGGGGNNN-NH2(W2G3)-and studied their coating ability on negatively charged liposomes. It was found that the coating was mainly driven by the electrostatic interaction between the peptides' cationic side groups and the acidic lipids, which also mediated the "anchoring " of Trp residuals in the interfacial region of lipid bilayers. At the same conditions, the amount of the coated W2R3 was more than that of W2K3, but the stability of the liposome coated with W2R3 was deteriorated. This was caused by the delocalized charge of the guanidinium group of arginine. The coating of the peptide rendered the liposome pH-responsive behavior but did not prominently change the phase transition temperature. The liposome coated with peptides displayed appropriate pH/temperature dual responsive characteristics and was able to release the content in a controlled manner
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Fluoresceins
|2 NLM
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|a Lipid Bilayers
|2 NLM
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|a Liposomes
|2 NLM
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|a Peptides
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|a Salts
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|a Water
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|a 059QF0KO0R
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|a DNA
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|a 9007-49-2
|2 NLM
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|a Arginine
|2 NLM
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|a 94ZLA3W45F
|2 NLM
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|a Guanidine
|2 NLM
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|a JU58VJ6Y3B
|2 NLM
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|a fluorexon
|2 NLM
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|a V0YM2B16TS
|2 NLM
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| 700 |
1 |
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|a Xia, Yuqiong
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Sun, Jianbo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Wang, Nan
|e verfasserin
|4 aut
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| 700 |
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|a Zhu, Lin
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Tao
|e verfasserin
|4 aut
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| 700 |
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|a Huang, Yanyi
|e verfasserin
|4 aut
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| 700 |
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|a Liang, Dehai
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 30(2014), 21 vom: 03. Juni, Seite 6219-27
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:30
|g year:2014
|g number:21
|g day:03
|g month:06
|g pages:6219-27
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|u http://dx.doi.org/10.1021/la501296r
|3 Volltext
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