From airway inflammation to inflammatory bowel disease : eotaxin-1, a key regulator of intestinal inflammation

Copyright © 2014 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 153(2014), 1 vom: 23. Juli, Seite 199-208
1. Verfasser: Adar, Tomer (VerfasserIn)
Weitere Verfasser: Shteingart, Shimon, Ben Ya'acov, Ami, Bar-Gil Shitrit, Ariella, Goldin, Eran
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Review Eosinophil Eotaxin Immune system Inflammatory bowel disease Anti-Inflammatory Agents Chemokine CCL11 Immunologic Factors Receptors, CCR
Beschreibung
Zusammenfassung:Copyright © 2014 Elsevier Inc. All rights reserved.
Eotaxin-1 (CCL-11) is a potent eosinophil chemoattractant that is considered a major contributor to tissue eosinophilia. Elevated eotaxin-1 levels have been described in various pathologic conditions, ranging from airway inflammation, to Hodgkin lymphoma, obesity and coronary artery disease. The main receptor for eotaxin-1 is CCR3; however, recent evidence indicates that eotaxin-1 may also bind to other receptors expressed by various cell types, suggesting a more widespread regulatory role for eotaxin-1 beyond the recruitment of eosinophils. Eotaxin-1 is also strongly associated with various gastrointestinal (GI) disorders. Although the etiology of inflammatory bowel disease (IBD) is still unknown, eotaxin-1 may play a key role in the development of mucosal inflammation. In this review, we summarize the biological context and effects of eotaxin-1, as well as its potential role as a therapeutic target, with a special focus on gastrointestinal inflammation
Beschreibung:Date Completed 12.09.2014
Date Revised 14.06.2014
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.04.012