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231224s2014 xx |||||o 00| ||eng c |
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7 |
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|a 10.1021/la5003447
|2 doi
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|a pubmed24n0792.xml
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Fong, Wye Khay
|e verfasserin
|4 aut
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| 245 |
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|a Generation of geometrically ordered lipid-based liquid-crystalline nanoparticles using biologically relevant enzymatic processing
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|c 2014
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|a Text
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|a ƒaComputermedien
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|a Date Completed 15.04.2015
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|a Date Revised 20.05.2014
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a High-symmetry lipid nanoparticles with internal bicontinuous cubic phase structure (cubosomes) are prepared from a simple emulsion containing a mixture of a nondigestible lipid (phytantriol) and a digestible short-chained triglyceride using enzymatic lipolysis of the incorporated short-chained triglyceride. The lipolytic products partition away from the nondigestible lipid, resulting in crystallization of the cubic-phase internal structure. Time-resolved small-angle X-ray scattering revealed the kinetics of the disorder-to-order transition, with cryo-transmission electron microscopy showing an absence of liposomes. The new approach offers a new "sideways" method for the generation of lipid-based nanostructured materials that avoids the problems of top-down and bottom-up approaches
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Enzymes
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|a Fatty Alcohols
|2 NLM
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|a 3,7,11,15-tetramethyl-1,2,3-hexadecanetriol
|2 NLM
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|a 8LVI07A72W
|2 NLM
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|a Salentinig, Stefan
|e verfasserin
|4 aut
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1 |
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|a Prestidge, Clive A
|e verfasserin
|4 aut
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1 |
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|a Mezzenga, Raffaele
|e verfasserin
|4 aut
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|a Hawley, Adrian
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|a Boyd, Ben J
|e verfasserin
|4 aut
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 30(2014), 19 vom: 20. Mai, Seite 5373-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:30
|g year:2014
|g number:19
|g day:20
|g month:05
|g pages:5373-7
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|u http://dx.doi.org/10.1021/la5003447
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