Plasmacytoid dendritic cells of the gut relevance to immunity and pathology

Plasmacytoid dendritic cells of the gut : relevance to immunity and pathology

Copyright © 2014. Published by Elsevier Inc.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 153(2014), 1 vom: 15. Juli, Seite 165-77
1. Verfasser: Lombardi, Vincent C (VerfasserIn)
Weitere Verfasser: Khaiboullina, Svetlana F
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Review Autoimmunity GALT; Gut; Interferon; Tolerance; mehr... pDC; Cytokines Toll-Like Receptors
Beschreibung
Zusammenfassung:Copyright © 2014. Published by Elsevier Inc.
Plasmacytoid dendritic cells (pDCs) are bone marrow-derived immune cells with the ability to express copious amounts of type I and III interferon (IFN) and can differentiate into antigen-presenting dendritic cells as a result of stimulation by pathogen-derived nucleic acid. These powerful combined functionalities allow pDCs to bridge the innate and adaptive immune systems resulting in a concerted pathogen response. The contribution of pDCs to gastrointestinal immunity is only now being elucidated and is proving to be a critical component in systemic immunity. This review will explore the immunology of pDCs and will discuss their involvement in human disease and tolerance with an emphasis on those in the gastrointestinal lymphoid tissue
Beschreibung:Date Completed 12.09.2014
Date Revised 21.10.2021
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.04.007