A case of urachal carcinoma with multiple lung metastases treated by TS-1/CDDP chemotherapy

A 67-year-old woman presented with macroscopic hematuria and lower abdominal pain. Cystoscopy revealed a broad-stalk non-papillary tumor at the bladder dome. Computed tomography (CT) showed a tumor extending from the umbilicus to the bladder dome, together with multiple lung metastases. Serum carcin...

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Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 60(2014), 3 vom: 15. März, Seite 147-50
1. Verfasser: Yoshida, Yasuyuki (VerfasserIn)
Weitere Verfasser: Yamanaka, Kazuaki, Ueda, Norichika, Hirai, Toshiaki, Kishikawa, Hidefumi, Nishimura, Kenji, Ichikawa, Yasuji
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Case Reports English Abstract Journal Article Antigens, Tumor-Associated, Carbohydrate Carcinoembryonic Antigen Drug Combinations carbohydrate antigen 199, human S 1 (combination) 150863-82-4 Tegafur mehr... 1548R74NSZ Oxonic Acid 5VT6420TIG
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100 1 |a Yoshida, Yasuyuki  |e verfasserin  |4 aut 
245 1 2 |a A case of urachal carcinoma with multiple lung metastases treated by TS-1/CDDP chemotherapy 
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520 |a A 67-year-old woman presented with macroscopic hematuria and lower abdominal pain. Cystoscopy revealed a broad-stalk non-papillary tumor at the bladder dome. Computed tomography (CT) showed a tumor extending from the umbilicus to the bladder dome, together with multiple lung metastases. Serum carcinoembryonic antigen and cancer antigen (CA19-9) levels were elevated at 7.0 ng/ml and 180 U/ml, respectively. Transurethral resection of the tumor was performed and histopathology revealed adenocarcinoma. Therefore, the tumor was diagnosed as a stage IVB (Sheldon's category) urachal carcinoma. En bloc segmental resection of the urachal carcinoma with the bladder dome was performed, followed by chemotherapy with tegafur, gimestat, and otastat potassium (TS-1) and cisplatin. The disease remained stable for 8 months. However, a follow up CT scan after 11 chemotherapy cycles showed progression of the lung metastases. In spite of the change to a second-line gemcitabine and cisplatin chemotherapy regimen, the disease continued to progress after 4 cycles 
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650 4 |a English Abstract 
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650 7 |a 5VT6420TIG  |2 NLM 
700 1 |a Yamanaka, Kazuaki  |e verfasserin  |4 aut 
700 1 |a Ueda, Norichika  |e verfasserin  |4 aut 
700 1 |a Hirai, Toshiaki  |e verfasserin  |4 aut 
700 1 |a Kishikawa, Hidefumi  |e verfasserin  |4 aut 
700 1 |a Nishimura, Kenji  |e verfasserin  |4 aut 
700 1 |a Ichikawa, Yasuji  |e verfasserin  |4 aut 
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