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20231224111510.0 |
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cr uuu---uuuuu |
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231224s2014 xx |||||o 00| ||eng c |
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7 |
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|a 10.1016/j.clim.2014.04.003
|2 doi
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| 028 |
5 |
2 |
|a pubmed24n0791.xml
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|a (DE-627)NLM237361035
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|a (NLM)24732074
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|a (PII)S1521-6616(14)00088-6
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Wang, Xiao
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The effect of polyamines on the binding of anti-DNA antibodies from patients with SLE and normal human subjects
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| 264 |
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1 |
|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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| 500 |
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|a Date Completed 12.09.2014
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| 500 |
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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| 520 |
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|a Published by Elsevier Inc.
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|a Antibodies to DNA (anti-DNA) are the serological hallmark of systemic lupus erythematosus (SLE). To elucidate specificity further, the effect of polyamines on the binding of anti-DNA antibodies from patients with lupus was tested by ELISA to calf thymus (CT) DNA; we also assessed the binding of plasmas of patients and normal human subjects (NHS) to Micrococcus luteus (MC) DNA. As these studies showed, spermine can dose-dependently inhibit SLE anti-DNA binding to CT DNA and can promote dissociation of preformed immune complexes. With MC DNA as antigen, spermine failed to inhibit the NHS anti-DNA binding. Studies using plasmas adsorbed to a CT DNA cellulose affinity indicated that SLE plasmas are mixtures of anti-DNA that differ in inhibition by spermine and binding to conserved and non-conserved determinants. Together, these studies demonstrate that spermine can influence the binding of anti-DNA autoantibodies and may contribute to the antigenicity of DNA
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| 650 |
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4 |
|a Journal Article
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| 650 |
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4 |
|a Research Support, N.I.H., Extramural
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| 650 |
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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4 |
|a Research Support, U.S. Gov't, Non-P.H.S.
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| 650 |
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4 |
|a Anti-DNA antibody;
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| 650 |
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4 |
|a Antigenicity;
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| 650 |
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4 |
|a Polyamines
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| 650 |
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4 |
|a SLE;
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| 650 |
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4 |
|a Spermine;
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| 650 |
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7 |
|a Antibodies, Antinuclear
|2 NLM
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| 650 |
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7 |
|a Antigen-Antibody Complex
|2 NLM
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| 650 |
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7 |
|a DNA, Bacterial
|2 NLM
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| 650 |
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7 |
|a Polyamines
|2 NLM
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| 650 |
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7 |
|a DNA
|2 NLM
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| 650 |
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7 |
|a 9007-49-2
|2 NLM
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| 650 |
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7 |
|a calf thymus DNA
|2 NLM
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| 650 |
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7 |
|a 91080-16-9
|2 NLM
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| 650 |
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7 |
|a Spermidine
|2 NLM
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| 650 |
|
7 |
|a U87FK77H25
|2 NLM
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| 700 |
1 |
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|a Stearns, Nancy A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Li, Xingfu
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Pisetsky, David S
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 1 vom: 07. Juli, Seite 94-103
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:153
|g year:2014
|g number:1
|g day:07
|g month:07
|g pages:94-103
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2014.04.003
|3 Volltext
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|a GBV_USEFLAG_A
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| 912 |
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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| 951 |
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|a AR
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| 952 |
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|d 153
|j 2014
|e 1
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|c 07
|h 94-103
|