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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.03.017
|2 doi
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|a pubmed24n0790.xml
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|a (NLM)24704464
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|a (PII)S1521-6616(14)00081-3
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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1 |
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|a Grönwall, Caroline
|e verfasserin
|4 aut
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1 |
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|a Relation of carotid plaque with natural IgM antibodies in patients with systemic lupus erythematosus
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 12.09.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Noninvasive carotid measurements have proven value in the estimation of future cardiovascular (CV) outcomes in systemic lupus erythematosus (SLE). Natural IgM-antibodies to phosphorylcholine (PC) epitopes can enhance apoptotic-cell clearance and induce anti-inflammatory pathways. Herein, we show that subclinical CV disease, as detected by carotid ultrasound, in a cross-sectional SLE cohort was associated with lower levels of IgM anti-PC, as well as lower levels of the ratio of IgM anti-PC/total IgM, compared to patients without plaque (p=0.004 and p=0.02, respectively). The IgM anti-PC/total IgM association remained significant after adjusting for age, cholesterol and hypertension. Adiponectin and sE-selectin were significantly elevated in patients with plaque, and statistical models showed that combining adiponectin, sE-selectin and IgM anti-PC/total IgM was better for predicting plaque than either test alone. These results support the hypothesis that IgM-natural autoantibodies may inhibit atherogenesis, and confirm the utility of IgM anti-PC levels as a biomarker for subclinical CV disease
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|a Journal Article
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|a Research Support, American Recovery and Reinvestment Act
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|a Research Support, N.I.H., Extramural
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Adiponectin
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|a Atherosclerosis
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|a E-selectin
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|a IgM
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|a Phosphorylcholine
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|a Systemic lupus erythematosus
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| 650 |
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|a Autoantibodies
|2 NLM
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| 650 |
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7 |
|a Biomarkers
|2 NLM
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| 650 |
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|a Immunoglobulin M
|2 NLM
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| 650 |
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|a Phosphorylcholine
|2 NLM
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| 650 |
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7 |
|a 107-73-3
|2 NLM
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| 700 |
1 |
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|a Reynolds, Harmony
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kim, June K
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Buyon, Jill
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Goldberg, Judith D
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Clancy, Robert M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Silverman, Gregg J
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 1 vom: 15. Juli, Seite 1-7
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|u http://dx.doi.org/10.1016/j.clim.2014.03.017
|3 Volltext
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