|
|
|
|
| LEADER |
01000caa a22002652c 4500 |
| 001 |
NLM236974378 |
| 003 |
DE-627 |
| 005 |
20250216210544.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1016/j.clim.2014.03.013
|2 doi
|
| 028 |
5 |
2 |
|a pubmed25n0789.xml
|
| 035 |
|
|
|a (DE-627)NLM236974378
|
| 035 |
|
|
|a (NLM)24691417
|
| 035 |
|
|
|a (PII)S1521-6616(14)00077-1
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Gong, Weihua
|e verfasserin
|4 aut
|
| 245 |
1 |
0 |
|a Role of myeloid-derived suppressor cells in mouse pre-sensitized cardiac transplant model
|
| 264 |
|
1 |
|c 2014
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 12.09.2014
|
| 500 |
|
|
|a Date Revised 03.12.2021
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2014 Elsevier Inc. All rights reserved.
|
| 520 |
|
|
|a Harness of sensitized transplantation remains a clinical challenge particularly in parallel with prolonged cold ischemia time (PCI)-mediated injury. Our present study was to test the role of myeloid-derived suppressor cells (MDSCs) in mouse pre-sensitized transplantation. Our findings revealed that CD11b+Gr1(low) MDSC was shown to have strong suppressive activity. MDSCs subsets from the tolerated mice exhibited higher suppressive capacities compared with counterparts from naive (untreated) mice. Depletion of Tregs could not affect splenic CD11b+Gr1(-low) MDSC frequency, but increase peripheral and intragraft CD11b+Gr1(-low) frequency. Intriguingly, boost of Tregs remarkably caused an increase of CD11b+Gr1(-low) frequency in the graft, peripheral blood, and spleen. Furthermore, peripheral CD11b+Gr1(-low) cells were massively accumulated at the early stage when allogeneic immune response was enhanced. Taken together, MDSCs could prevent grafts from PCI-mediated injury independent on Tregs in the pre-sensitized transplant recipients. Utilization of MDSC subset particularly CD11b+Gr1(-low) might provide a novel insight into improving graft outcome under such clinical scenarios
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a Research Support, Non-U.S. Gov't
|
| 650 |
|
4 |
|a Myeloid-derived suppressor cells
|
| 650 |
|
4 |
|a Prolonged cold ischemia time
|
| 650 |
|
4 |
|a Regulatory T cells
|
| 650 |
|
4 |
|a Sensitization
|
| 650 |
|
7 |
|a CD11b Antigen
|2 NLM
|
| 650 |
|
7 |
|a Gr-1 protein, mouse
|2 NLM
|
| 650 |
|
7 |
|a Receptors, Chemokine
|2 NLM
|
| 700 |
1 |
|
|a Ge, Fangmin
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Dahai
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Wu, Yan
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Liu, Fangbing
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Kim, Beom Seok
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Huang, Tao
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Koulmanda, Maria
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Robson, Simon C
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Strom, Terry B
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 1 vom: 28. Juli, Seite 8-16
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnas
|
| 773 |
1 |
8 |
|g volume:153
|g year:2014
|g number:1
|g day:28
|g month:07
|g pages:8-16
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2014.03.013
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_11
|
| 912 |
|
|
|a GBV_ILN_24
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 153
|j 2014
|e 1
|b 28
|c 07
|h 8-16
|