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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.03.012
|2 doi
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|a pubmed25n0789.xml
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|a (DE-627)NLM236919946
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|a (NLM)24685748
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|a (PII)S1521-6616(14)00076-X
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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|a Mongini, Patricia K A
|e verfasserin
|4 aut
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|a Candidate chromosome 1 disease susceptibility genes for Sjogren's syndrome xerostomia are narrowed by novel NOD.B10 congenic mice
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 12.09.2014
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a Sjogren's syndrome (SS) is characterized by salivary gland leukocytic infiltrates and impaired salivation (xerostomia). Cox-2 (Ptgs2) is located on chromosome 1 within the span of the Aec2 region. In an attempt to demonstrate that COX-2 drives antibody-dependent hyposalivation, NOD.B10 congenic mice bearing a Cox-2flox gene were generated. A congenic line with non-NOD alleles in Cox-2-flanking genes failed manifest xerostomia. Further backcrossing yielded disease-susceptible NOD.B10 Cox-2flox lines; fine genetic mapping determined that critical Aec2 genes lie within a 1.56 to 2.17Mb span of DNA downstream of Cox-2. Bioinformatics analysis revealed that susceptible and non-susceptible lines exhibit non-synonymous coding SNPs in 8 protein-encoding genes of this region, thereby better delineating candidate Aec2 alleles needed for SS xerostomia
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Research Support, Non-U.S. Gov't
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|a B lymphocytes
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|a Cyclooxygenase-2
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|a Genetic susceptibility
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|a NOD mice
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|a Sjogren's syndrome
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|a Cyclooxygenase 2
|2 NLM
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| 650 |
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|a EC 1.14.99.1
|2 NLM
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| 700 |
1 |
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|a Kramer, Jill M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Ishikawa, Tomo-O
|e verfasserin
|4 aut
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| 700 |
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|a Herschman, Harvey
|e verfasserin
|4 aut
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| 700 |
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|a Esposito, Donna
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 153(2014), 1 vom: 24. Juli, Seite 79-90
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:153
|g year:2014
|g number:1
|g day:24
|g month:07
|g pages:79-90
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|u http://dx.doi.org/10.1016/j.clim.2014.03.012
|3 Volltext
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