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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1021/la404739f
|2 doi
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|a pubmed25n0789.xml
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|a (DE-627)NLM236852507
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|a (NLM)24678792
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
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|a Ghosh, Dhiman
|e verfasserin
|4 aut
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| 245 |
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|a Complexation of amyloid fibrils with charged conjugated polymers
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 13.04.2015
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|a Date Revised 10.12.2019
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a It has been suggested that conjugated charged polymers are amyloid imaging agents and promising therapeutic candidates for neurological disorders. However, very less is known about their efficacy in modulating the amyloid aggregation pathway. Here, we studied the modulation of Parkinson's disease associated α-synuclein (AS) amyloid assembly kinetics using conjugated polyfluorene polymers (PF, cationic; PFS, anionic). We also explored the complexation of these charged polymers with the various AS aggregated species including amyloid fibrils and oligomers using multidisciplinary biophysical techniques. Our data suggests that both polymers irrespective of their different charges in the side chains increase the fibrilization kinetics of AS and also remarkably change the morphology of the resultant amyloid fibrils. Both polymers were incorporated/aligned onto the AS amyloid fibrils as evident from electron microscopy (EM) and atomic force microscopy (AFM), and the resultant complexes were structurally distinct from their pristine form of both polymers and AS supported by FTIR study. Additionally, we observed that the mechanism of interactions between the polymers with different species of AS aggregates were markedly different
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Amyloid
|2 NLM
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|a Benzothiazoles
|2 NLM
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|a Fluorocarbon Polymers
|2 NLM
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|a Protein Aggregates
|2 NLM
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|a Recombinant Proteins
|2 NLM
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|a Solutions
|2 NLM
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|a Thiazoles
|2 NLM
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|a alpha-Synuclein
|2 NLM
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|a thioflavin T
|2 NLM
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|a 2390-54-7
|2 NLM
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|a Dutta, Paulami
|e verfasserin
|4 aut
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|a Chakraborty, Chanchal
|e verfasserin
|4 aut
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| 700 |
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|a Singh, Pradeep K
|e verfasserin
|4 aut
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|a Anoop, A
|e verfasserin
|4 aut
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| 700 |
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|a Jha, Narendra Nath
|e verfasserin
|4 aut
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| 700 |
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|a Jacob, Reeba S
|e verfasserin
|4 aut
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|a Mondal, Mrityunjoy
|e verfasserin
|4 aut
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|a Mankar, Shruti
|e verfasserin
|4 aut
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|a Das, Subhadeep
|e verfasserin
|4 aut
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|a Malik, Sudip
|e verfasserin
|4 aut
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| 700 |
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|a Maji, Samir K
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 30(2014), 13 vom: 08. Apr., Seite 3775-86
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
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|g volume:30
|g year:2014
|g number:13
|g day:08
|g month:04
|g pages:3775-86
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|u http://dx.doi.org/10.1021/la404739f
|3 Volltext
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|h 3775-86
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