Directed axonal outgrowth using a propagating gradient of IGF-1

Directed axonal outgrowth using a propagating gradient of IGF-1

© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 26(2014), 29 vom: 06. Aug., Seite 4936-40
1. Verfasser: Lee, Wonjae (VerfasserIn)
Weitere Verfasser: Frank, Curtis W, Park, Jon
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't axon guidance controlled drug release hydrogel tissue engineering Drug Carriers Polylactic Acid-Polyglycolic Acid Copolymer 1SIA8062RS Polyglycolic Acid mehr... 26009-03-0 Lactic Acid 33X04XA5AT Insulin-Like Growth Factor I 67763-96-6
Beschreibung
Zusammenfassung:© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
The temporospatial regulation of axon outgrowth is useful for guiding de novo connectivity or re-connectivity of neurons in neurological injury or disease. Here we report the successful construction of a biocompatible guidance device, in which a linear propagation of IGF-1 gradient sequentially directs axon outgrowth. We observe the extensive in vitro axonal extension over 5 mm with a desired growth rate of ∼ 1 mm/day
Beschreibung:Date Completed 31.08.2015
Date Revised 30.09.2020
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201305995