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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.03.003
|2 doi
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|a pubmed24n1223.xml
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|a (DE-627)NLM236652443
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|a (NLM)24657713
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|a (PII)S1521-6616(14)00056-4
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Lee, Naeun
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Human monocytes have increased IFN-γ-mediated IL-15 production with age alongside altered IFN-γ receptor signaling
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.07.2014
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a IL-15 is involved in regulating host defense and inflammation. Monocytes produce the biologically active cell surface IL-15 in response to IFN-γ. Although aging can alter the immune system, little is known about whether and how aging affects IFN-γ-mediated IL-15 production in human monocytes. We showed that monocytes of healthy older adults (age ≥ 65) had increased cell surface IL-15 expression in response to IFN-γ compared to those of healthy young adults (age ≤ 40). This finding stems in part from increased IFN-γ receptor (R)1/2 expression on monocytes in older adults, leading to enhanced STAT1 activation and interferon regulatory factor 1 synthesis with increased IL15 gene expression. Our study suggests that with aging the IFN-γ-mediated IL-15 production pathway in human monocytes is uncompromised, but rather augmented, and could be considered as a therapeutic target point to modulate host defense and inflammation in older adults
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Human
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4 |
|a IFN-γ
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| 650 |
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4 |
|a IL-15
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| 650 |
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4 |
|a Monocytes and aging
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| 650 |
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7 |
|a IL15RA protein, human
|2 NLM
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| 650 |
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|a IRF1 protein, human
|2 NLM
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| 650 |
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7 |
|a Interferon Regulatory Factor-1
|2 NLM
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| 650 |
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|a Interleukin-15
|2 NLM
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| 650 |
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|a Receptors, Interferon
|2 NLM
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| 650 |
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7 |
|a Receptors, Interleukin-15
|2 NLM
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| 650 |
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|a STAT1 Transcription Factor
|2 NLM
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| 650 |
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7 |
|a STAT1 protein, human
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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7 |
|a 82115-62-6
|2 NLM
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| 700 |
1 |
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|a Shin, Min Sun
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Ki Soo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Yoo, Seung-Ah
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mohanty, Subhasis
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Montgomery, Ruth R
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Shaw, Albert C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kang, Insoo
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 152(2014), 1-2 vom: 21. Mai, Seite 101-10
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
8 |
|g volume:152
|g year:2014
|g number:1-2
|g day:21
|g month:05
|g pages:101-10
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2014.03.003
|3 Volltext
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|d 152
|j 2014
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|c 05
|h 101-10
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