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231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
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|a 10.1021/la500412r
|2 doi
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|a pubmed24n0788.xml
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|a DE-627
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|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Smith, Cartney E
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Cross-linkable liposomes stabilize a magnetic resonance contrast-enhancing polymeric fastener
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| 264 |
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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| 338 |
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|a ƒa Online-Ressource
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|2 rdacarrier
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| 500 |
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|a Date Completed 13.04.2015
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| 500 |
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|a Date Revised 21.10.2021
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Liposomes are commonly used to deliver drugs and contrast agents to their target site in a controlled manner. One of the greatest obstacles in the performance of such delivery vehicles is their stability in the presence of serum. Here, we demonstrate a method to stabilize a class of liposomes that load gadolinium, a magnetic resonance (MR) contrast agent, as a model cargo on their surfaces. We hypothesized that the sequential adsorption of a gadolinium-binding chitosan fastener on the liposome surface followed by covalent cross-linking of the lipid bilayer would provide enhanced stability and improved MR signal in the presence of human serum. To investigate this hypothesis, liposomes composed of diyne-containing lipids were assembled and functionalized via chitosan conjugated with a hydrophobic anchor and diethylenetriaminepentaacetic acid (DTPA). This postadsorption cross-linking strategy served to stabilize the thermodynamically favorable association between liposome and polymeric fastener. Furthermore, the chitosan-coated, cross-linked liposomes proved more effective as delivery vehicles of gadolinium than uncross-linked liposomes due to the reduced liposome degradation and chitosan desorption. Overall, this study demonstrates a useful method to stabilize a broad class of particles used for systemic delivery of various molecular payloads
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| 650 |
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4 |
|a Journal Article
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| 650 |
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|a Research Support, N.I.H., Extramural
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4 |
|a Research Support, Non-U.S. Gov't
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| 650 |
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|a Contrast Media
|2 NLM
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| 650 |
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|a Diynes
|2 NLM
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| 650 |
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|a Liposomes
|2 NLM
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| 650 |
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|a Phosphatidylcholines
|2 NLM
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| 650 |
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|a 1,2-bis(10,12-tricosadiynoyl)phosphatidylcholine
|2 NLM
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| 650 |
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7 |
|a 76078-28-9
|2 NLM
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| 650 |
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|a Pentetic Acid
|2 NLM
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| 650 |
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|a 7A314HQM0I
|2 NLM
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| 650 |
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|a Chitosan
|2 NLM
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| 650 |
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|a 9012-76-4
|2 NLM
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| 650 |
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|a Gadolinium
|2 NLM
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| 650 |
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7 |
|a AU0V1LM3JT
|2 NLM
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| 700 |
1 |
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|a Kong, Hyunjoon
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1992
|g 30(2014), 13 vom: 08. Apr., Seite 3697-704
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnns
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| 773 |
1 |
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|g volume:30
|g year:2014
|g number:13
|g day:08
|g month:04
|g pages:3697-704
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| 856 |
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|u http://dx.doi.org/10.1021/la500412r
|3 Volltext
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