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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.03.001
|2 doi
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|a pubmed24n0788.xml
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|a (DE-627)NLM236423843
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|a (NLM)24632064
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|a (PII)S1521-6616(14)00054-0
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Boita, Monica
|e verfasserin
|4 aut
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| 245 |
1 |
4 |
|a The molecular and functional characterization of clonally expanded CD8+ TCR BV T cells in eosinophilic granulomatosis with polyangiitis (EGPA)
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.07.2014
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a In eosinophilic granulomatosis with polyangiitis (EGPA) clonally expanded T cells might concur in granuloma formation and vascular injury. The TCR β-variable (BV) chain repertoire and third complementarity determining region (CDR3) of peripheral CD4+ and CD8+ cells in EGPA patients and age-matched controls and the expression of cytokines and chemokine receptors were investigated. The CD8+ lymphocytes of EGPA patients showed an increased frequency of BV expansions with a skewed profile of BV CDR3 lengths, increased CCR5 and CXCR3 expression and increased INFγ and TNFα production. In two patients, the TCR CDR3 cDNA sequences of the expanded BV family were identified. The CD4+ lymphocytes of EGPA patients revealed a higher expression of CRTH2 and increased production of IL-5. In conclusion, CD4+ T cells display a Th2 profile and CD8+ T cells are clonally expanded in EGPA and have a proinflammatory phenotype, suggesting their pathogenic role in vasculitic damage
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|a Journal Article
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|a CD8+ lymphocytes
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| 650 |
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|a EGPA
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| 650 |
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|a Proinflammatory cytokines
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| 650 |
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|a TCR BV
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| 650 |
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|a Vasculitis
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| 650 |
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|a Biomarkers
|2 NLM
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| 650 |
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|a CCR5 protein, human
|2 NLM
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| 650 |
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|a CXCR3 protein, human
|2 NLM
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| 650 |
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|a Complementarity Determining Regions
|2 NLM
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| 650 |
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|a Interleukin-5
|2 NLM
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| 650 |
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7 |
|a Receptors, Antigen, T-Cell, alpha-beta
|2 NLM
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| 650 |
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7 |
|a Receptors, CCR5
|2 NLM
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| 650 |
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|a Receptors, CXCR3
|2 NLM
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| 650 |
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|a Receptors, Immunologic
|2 NLM
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| 650 |
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7 |
|a Receptors, Prostaglandin
|2 NLM
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| 650 |
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7 |
|a Tumor Necrosis Factor-alpha
|2 NLM
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| 650 |
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|a Interferon-gamma
|2 NLM
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| 650 |
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|a 82115-62-6
|2 NLM
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| 650 |
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|a prostaglandin D2 receptor
|2 NLM
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|a XZF106QU24
|2 NLM
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| 700 |
1 |
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|a Guida, Giuseppe
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Circosta, Paola
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Elia, Angela Rita
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Stella, Stefania
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Heffler, Enrico
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Badiu, Iuliana
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Martorana, Davide
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Mariani, Sara
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Rolla, Giovanni
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Cignetti, Alessandro
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 152(2014), 1-2 vom: 01. Mai, Seite 152-63
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:152
|g year:2014
|g number:1-2
|g day:01
|g month:05
|g pages:152-63
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| 856 |
4 |
0 |
|u http://dx.doi.org/10.1016/j.clim.2014.03.001
|3 Volltext
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| 912 |
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|a GBV_USEFLAG_A
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| 912 |
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|a SYSFLAG_A
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|a GBV_NLM
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|a GBV_ILN_11
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| 912 |
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|a GBV_ILN_24
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| 912 |
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|a GBV_ILN_350
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|a AR
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| 952 |
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|d 152
|j 2014
|e 1-2
|b 01
|c 05
|h 152-63
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