Reversible non-stick behaviour of a bacterial protein polymer provides a tuneable molecular mimic for cell and tissue engineering

Reversible non-stick behaviour of a bacterial protein polymer provides a tuneable molecular mimic for cell and tissue engineering

© The Authors, 2014. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Bibliographische Detailangaben
Veröffentlicht in:Advanced materials (Deerfield Beach, Fla.). - 1998. - 26(2014), 17 vom: 05. Mai, Seite 2704-9, 2616
1. Verfasser: Roque, Ana I (VerfasserIn)
Weitere Verfasser: Soliakov, Andrei, Birch, Mark A, Philips, Sion R, Shah, Deepan S H, Lakey, Jeremy H
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Advanced materials (Deerfield Beach, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't Bacterial Proteins Extracellular Matrix Proteins Recombinant Fusion Proteins caf1 protein, Yersinia pestis
Beschreibung
Zusammenfassung:© The Authors, 2014. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Yersina pestis, the bubonic plague bacterium, is coated with a polymeric protein hydrogel for protection from host defences. The protein, which is robust and non-stick, resembles structures found in many eukaryotic extracellular-matrix proteins. Cells grown on the natural polymer cannot adhere and grow poorly; however, when cell-adhesion motifs are inserted into the protein, the cells proliferate
Beschreibung:Date Completed 17.04.2015
Date Revised 21.03.2024
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-4095
DOI:10.1002/adma.201304645