Modelling transcriptional networks in leaf senescence
© The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com.
| Veröffentlicht in: | Journal of experimental botany. - 1985. - 65(2014), 14 vom: 18. Juli, Seite 3859-73 |
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| Format: | Online-Aufsatz |
| Sprache: | English |
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2014
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| Zugriff auf das übergeordnete Werk: | Journal of experimental botany |
| Schlagworte: | Journal Article Research Support, Non-U.S. Gov't Review Gene regulation modelling senescence systems biology transcriptional networks. |
| Zusammenfassung: | © The Author 2014. Published by Oxford University Press on behalf of the Society for Experimental Biology. All rights reserved. For permissions, please email: journals.permissionsoup.com. The process of leaf senescence is induced by an extensive range of developmental and environmental signals and controlled by multiple, cross-linking pathways, many of which overlap with plant stress-response signals. Elucidation of this complex regulation requires a step beyond a traditional one-gene-at-a-time analysis. Application of a more global analysis using statistical and mathematical tools of systems biology is an approach that is being applied to address this problem. A variety of modelling methods applicable to the analysis of current and future senescence data are reviewed and discussed using some senescence-specific examples. Network modelling with a senescence transcriptome time course followed by testing predictions with gene-expression data illustrates the application of systems biology tools |
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| Beschreibung: | Date Completed 30.03.2015 Date Revised 23.07.2014 published: Print-Electronic Citation Status MEDLINE |
| ISSN: | 1460-2431 |
| DOI: | 10.1093/jxb/eru054 |