Rechallenge of everolimus for metastatic renal cell carcinoma after recovery from grade 3 interstitial lung disease : a case report

We report a case of the rechallenge of everolimus for metastatic renal cell carcinoma (RCC) after successful recovery from grade 3 interstitial lung disease (ILD). A 76-year-old man with metastatic RCC developed grade 3 ILD one month after the initiation of everolimus therapy (10 mg/day). ILD subsid...

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Bibliographische Detailangaben
Veröffentlicht in:Hinyokika kiyo. Acta urologica Japonica. - 1962. - 60(2014), 1 vom: 26. Jan., Seite 25-8
1. Verfasser: Utsunomiya, Noriaki (VerfasserIn)
Weitere Verfasser: Kono, Yuka, Matsumoto, Keiyu, Matsumoto, Takeshi, Nakagawa, Atsushi, Tsunemori, Hiroyuki, Okada, Takuya, Muguruma, Koei, Kawakita, Mutsushi
Format: Aufsatz
Sprache:Japanese
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Hinyokika kiyo. Acta urologica Japonica
Schlagworte:Case Reports Journal Article Antineoplastic Agents Enzyme Inhibitors Everolimus 9HW64Q8G6G Prednisolone 9PHQ9Y1OLM TOR Serine-Threonine Kinases EC 2.7.11.1 mehr... Sirolimus W36ZG6FT64
Beschreibung
Zusammenfassung:We report a case of the rechallenge of everolimus for metastatic renal cell carcinoma (RCC) after successful recovery from grade 3 interstitial lung disease (ILD). A 76-year-old man with metastatic RCC developed grade 3 ILD one month after the initiation of everolimus therapy (10 mg/day). ILD subsided in 4 months after the withdrawal of everolimus and treatment with corticosteroids. Half dose (5 mg/day) of everolimus was rechallenged for 9 months until another grade 3 ILD developed. Everolimus kept the disease under control for 13 months including the discontinuation period
Beschreibung:Date Completed 13.05.2014
Date Revised 03.12.2021
published: Print
Citation Status MEDLINE
ISSN:0018-1994