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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2014.02.004
|2 doi
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|a pubmed24n0786.xml
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|a (DE-627)NLM235916358
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|a (NLM)24576620
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|a (PII)S1521-6616(14)00041-2
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Szymula, Agnieszka
|e verfasserin
|4 aut
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| 245 |
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|a T cell epitope mimicry between Sjögren's syndrome Antigen A (SSA)/Ro60 and oral, gut, skin and vaginal bacteria
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 02.07.2014
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|a Date Revised 31.03.2022
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 Elsevier Inc. All rights reserved.
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|a This study was undertaken to test the hypothesis that Sjogren's syndrome Antigen A (SSA)/Ro60-reactive T cells are activated by peptides originating from oral and gut bacteria. T cell hybridomas generated from HLA-DR3 transgenic mice recognized 3 regions on Ro60, with core epitopes mapped to amino acids 228-238, 246-256 and 371-381. BLAST analysis identified several mimicry peptides, originating from human oral, intestinal, skin and vaginal bacteria, as well as environmental bacteria. Amongst these, a peptide from the von Willebrand factor type A domain protein (vWFA) from the oral microbe Capnocytophaga ochracea was the most potent activator. Further, Ro60-reactive T cells were activated by recombinant vWFA protein and whole Escherichia coli expressing this protein. These results demonstrate that peptides derived from normal human microbiota can activate Ro60-reactive T cells. Thus, immune responses to commensal microbiota and opportunistic pathogens should be explored as potential triggers for initiating autoimmunity in SLE and Sjögren's syndrome
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|a Journal Article
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|a Research Support, N.I.H., Extramural
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|a Microbiota
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|a Molecular mimicry
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|a Ro60/SSA
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|a SLE
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|a Sjögren's syndrome
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|a T epitopes
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|a Epitopes, T-Lymphocyte
|2 NLM
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|a HLA-DR3 Antigen
|2 NLM
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|a Peptides
|2 NLM
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|a Recombinant Proteins
|2 NLM
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|a Ribonucleoproteins
|2 NLM
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|a SS-A antigen
|2 NLM
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| 650 |
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|a von Willebrand Factor
|2 NLM
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| 700 |
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|a Rosenthal, Jacob
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Szczerba, Barbara M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Bagavant, Harini
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Fu, Shu Man
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Deshmukh, Umesh S
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 152(2014), 1-2 vom: 01. Mai, Seite 1-9
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
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|g volume:152
|g year:2014
|g number:1-2
|g day:01
|g month:05
|g pages:1-9
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|u http://dx.doi.org/10.1016/j.clim.2014.02.004
|3 Volltext
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