T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells

T cell-specific BLIMP-1 deficiency exacerbates experimental autoimmune encephalomyelitis in nonobese diabetic mice by increasing Th1 and Th17 cells

Copyright © 2014 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 151(2014), 2 vom: 25. Apr., Seite 101-13
1. Verfasser: Lin, Ming-Hong (VerfasserIn)
Weitere Verfasser: Yeh, Li-Tzu, Chen, Shyi-Jou, Chiou, Hsin-Ying C, Chu, Chin-Chen, Yen, Linju B, Lin, Kuo-I, Chang, Deh-Ming, Sytwu, Huey-Kang
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't BLIMP-1 EAE IL-10 Th1 Th17 Treg Prdm1 protein, mouse STAT3 Transcription Factor mehr... STAT4 Transcription Factor Stat3 protein, mouse Stat4 protein, mouse Transcription Factors Positive Regulatory Domain I-Binding Factor 1 EC 2.1.1.-
Beschreibung
Zusammenfassung:Copyright © 2014 Elsevier Inc. All rights reserved.
Recently, we demonstrated that B lymphocyte-induced maturation protein 1 (BLIMP-1) has a role in regulating the differentiation and effector function of Th1 and Th17 cells. As these cells play critical roles in the induction and pathogenesis of experimental autoimmune encephalomyelitis (EAE), we investigated the potential role of T cell BLIMP-1 in modulating MOG35-55-induced EAE. We established T cell-specific BLIMP-1 conditional knockout (CKO) NOD mice to dissect the role of BLIMP-1 in EAE using loss-of-function model. Our results indicate that EAE severity is dramatically exacerbated in CKO mice. The numbers of CNS-infiltrating Th1, Th17, IFN-γ(+)IL-17A(+), and IL-21(+)IL-17A(+) CD4(+) T cells are remarkably increased in brain and spinal cord of CKO mice. Moreover, the ratio of Tregs/effectors and IL-10 production of Tregs are significantly downregulated in CNS of CKO mice. We conclude that BLIMP-1 suppresses autoimmune encephalomyelitis via downregulating Th1 and Th17 cells and impairing Treg cells
Beschreibung:Date Completed 16.05.2014
Date Revised 16.11.2017
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2014.02.006