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20250216160224.0 |
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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1016/j.clim.2013.12.003
|2 doi
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|a pubmed25n0784.xml
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|a (DE-627)NLM235217352
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|a (NLM)24503171
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|a (PII)S1521-6616(13)00322-7
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|a DE-627
|b ger
|c DE-627
|e rakwb
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|a eng
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| 100 |
1 |
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|a Hallstrand, Teal S
|e verfasserin
|4 aut
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1 |
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|a Airway epithelial regulation of pulmonary immune homeostasis and inflammation
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|c 2014
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| 336 |
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 10.04.2014
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|a Date Revised 13.12.2023
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2013 Elsevier Inc. All rights reserved.
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|a Recent genetic, structural and functional studies have identified the airway and lung epithelium as a key orchestrator of the immune response. Further, there is now strong evidence that epithelium dysfunction is involved in the development of inflammatory disorders of the lung. Here we review the characteristic immune responses that are orchestrated by the epithelium in response to diverse triggers such as pollutants, cigarette smoke, bacterial peptides, and viruses. We focus in part on the role of epithelium-derived interleukin (IL)-25, IL-33 and thymic stromal lymphopoietin (TSLP), as well as CC family chemokines as critical regulators of the immune response. We cite examples of the function of the epithelium in host defense and the role of epithelium dysfunction in the development of inflammatory diseases
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|a Journal Article
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|a Review
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|a Asthma
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| 650 |
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4 |
|a Chemokine
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| 650 |
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4 |
|a Chronic-obstructive pulmonary disease
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| 650 |
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4 |
|a Epithelium
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| 650 |
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4 |
|a Host defense
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| 650 |
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4 |
|a Tight junctions
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| 650 |
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|a Air Pollutants
|2 NLM
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| 650 |
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7 |
|a Bacterial Proteins
|2 NLM
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| 650 |
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7 |
|a Chemokines, CC
|2 NLM
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| 650 |
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7 |
|a Cytokines
|2 NLM
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| 650 |
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7 |
|a IL25 protein, human
|2 NLM
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| 650 |
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7 |
|a IL33 protein, human
|2 NLM
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| 650 |
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7 |
|a Interleukin-17
|2 NLM
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| 650 |
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7 |
|a Interleukin-33
|2 NLM
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| 650 |
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7 |
|a Interleukins
|2 NLM
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| 650 |
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7 |
|a Smoke
|2 NLM
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| 650 |
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7 |
|a Thymic Stromal Lymphopoietin
|2 NLM
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| 650 |
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7 |
|a GT0IL38SP4
|2 NLM
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| 700 |
1 |
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|a Hackett, Tillie L
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Altemeier, William A
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Matute-Bello, Gustavo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Hansbro, Philip M
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Knight, Darryl A
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Clinical immunology (Orlando, Fla.)
|d 1999
|g 151(2014), 1 vom: 25. März, Seite 1-15
|w (DE-627)NLM098196855
|x 1521-7035
|7 nnns
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| 773 |
1 |
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|g volume:151
|g year:2014
|g number:1
|g day:25
|g month:03
|g pages:1-15
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| 856 |
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|u http://dx.doi.org/10.1016/j.clim.2013.12.003
|3 Volltext
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|d 151
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