Thermoresponsive composite hydrogels with aligned macroporous structure by ice-templated assembly

Natural tissues, such as bone, tendon, and muscle, have well defined hierarchical structures, which are crucial for their biological and mechanical functions. However, mimicking these structural features still remains a great challenge. In this study, we use ice-templated assembly and UV-initiated c...

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Veröffentlicht in:Chemistry of materials : a publication of the American Chemical Society. - 1998. - 25(2013), 22 vom: 26. Okt., Seite 4551-4556
1. Verfasser: Bai, Hao (VerfasserIn)
Weitere Verfasser: Polini, Alessandro, Delattre, Benjamin, Tomsia, Antoni P
Format: Aufsatz
Sprache:English
Veröffentlicht: 2013
Zugriff auf das übergeordnete Werk:Chemistry of materials : a publication of the American Chemical Society
Schlagworte:Journal Article bio inspired composite freeze casting hydrogel nacre
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520 |a Natural tissues, such as bone, tendon, and muscle, have well defined hierarchical structures, which are crucial for their biological and mechanical functions. However, mimicking these structural features still remains a great challenge. In this study, we use ice-templated assembly and UV-initiated cryo-polymerization to fabricate a novel kind of composite hydrogel which have both aligned macroporous structure at micrometer scale and a nacre-like layered structure at nanoscale. Such hydrogels are macroporous, thermoresponsive, and exhibit excellent mechanical performance (tough and high stretchable), attractive properties that are of significant impact on the wide applications of composite hydrogels, especially as tissue-engineering scaffolds. The fabrication method in this study including freeze-casting and cryo-polymerization can also be applied to other materials, which makes it promising for designing and developing smart and multifunctional composite hydrogels with hierar chical structures 
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700 1 |a Delattre, Benjamin  |e verfasserin  |4 aut 
700 1 |a Tomsia, Antoni P  |e verfasserin  |4 aut 
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