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DE-627 |
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20250216152638.0 |
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231224s2013 xx ||||| 00| ||chi c |
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|a pubmed25n0783.xml
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|a (DE-627)NLM235041319
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|a (NLM)24484557
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a chi
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| 100 |
1 |
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|a Chen, Shi
|e verfasserin
|4 aut
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| 245 |
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|a Efficacy of sublingual immunotherapy with Dermatophagoides farinae drops in preschool and school-age children with allergic asthma and allergic rhinitis
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1 |
|c 2013
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|a Text
|b txt
|2 rdacontent
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| 337 |
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|a ohne Hilfsmittel zu benutzen
|b n
|2 rdamedia
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| 338 |
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|a Band
|b nc
|2 rdacarrier
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| 500 |
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|a Date Completed 04.09.2014
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|a Date Revised 07.06.2016
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|a published: Print
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|a Citation Status MEDLINE
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|a OBJECTIVE: To evaluate the efficacy of specific sublingual immunotherapy (SLIT) with Dermatophagoides farinae drops on children with allergic asthma and allergic rhinitis of the preschool and school-age groups of children and adolescents
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| 520 |
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|a METHOD: This study analyzed the efficacy of SLIT in 122 children (aged 3-14 yr) with house dust mites-induced allergic asthma and allergic rhinitis. According to the age, patients were defined as the preschool group ( ≤ 6 years old, n = 59) and school-age group (> 6 years old, n = 63). All children were treated with Dermatophagoides farinae drops for at least 2 years. Clinical observation and follow-up study were conducted during the treatment. Before and after SLIT for half a year, 1 year and 2 years, asthma symptom scores (day and night), rhinitis symptom scores and medication scores were evaluated. The adverse events were assessed during the study
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| 520 |
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|a RESULT: After SLIT for half a year, 1 year and 2 years, there were no significant differences between the preschool group (0.3 ± 0.5,0.0 ± 0.1,0.0 ± 0.0) and school-age group (0.3 ± 0.4,0.0 ± 0.1,0.0 ± 0.0) in day scores of asthma (Z value was -1.687, -0.613,0.000, all P > 0.05). There were no significant differences between the preschool group (0.2 ± 0.5,0.1 ± 0.3,0.0 ± 0.0) and school-age group (0.2 ± 0.4,0.1 ± 0.3, 0.0 ± 0.0) in night scores of asthma (Z value was -0.496, -0.486,0.000, all P > 0.05). There was no significant differences between the preschool group (1.4 ± 0.9,0.4 ± 0.5,0.1 ± 0.3) and school-age group (1.3 ± 0.9,0.5 ± 0.6,0.2 ± 0.4) in symptom scores of allergic rhinitis (Z value was -0.394, -1.166, -1.075, all P > 0.05). There were no significant differences between the preschool group (1.6 ± 0.8,0.0 ± 0.0,0.0 ± 0.0) and school-age group (1.7 ± 0.7,0.0 ± 0.0,0.0 ± 0.0) in medication scores of allergic rhinitis (Z value was -0.655,0.000,0.000, all P > 0.05). After SLIT for 2 years, most children in the preschool and school-age groups were no longer using asthma controlling medication, with no significant difference between the two groups (Z value was 0.000, P > 0.05). The overall incidence of adverse reactions was only 7%, and there was no significant difference in the incidence of adverse reactions between the two groups (χ(2) = 0.000, P > 0.05). The local adverse events were mild gastrointestinal discomfort and rash, a majority of local adverse events in the preschool group were diarrhea. No severe adverse events happened in the treatment
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|a CONCLUSION: SLIT with Dermatophagoides farinae drops is safe and effective in children with allergic asthma and allergic rhinitis of the preschool and school-age groups of children and adolescents, which provides evidences for early SLIT intervention of the disease
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|a English Abstract
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|a Journal Article
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|a Observational Study
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| 650 |
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|a Research Support, Non-U.S. Gov't
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| 650 |
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7 |
|a Antigens, Dermatophagoides
|2 NLM
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| 700 |
1 |
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|a Wang, Ling
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Liao, Feng
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Zeng, Xia
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Xing, Qiong-bo
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Chen, Bing
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Xiao-zhen
|e verfasserin
|4 aut
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| 773 |
0 |
8 |
|i Enthalten in
|t Zhonghua er ke za zhi = Chinese journal of pediatrics
|d 1960
|g 51(2013), 11 vom: 31. Nov., Seite 831-5
|w (DE-627)NLM136249191
|x 0578-1310
|7 nnns
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| 773 |
1 |
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|g volume:51
|g year:2013
|g number:11
|g day:31
|g month:11
|g pages:831-5
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| 912 |
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|a GBV_ILN_11
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|a GBV_ILN_20
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|a GBV_ILN_120
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|a GBV_ILN_130
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|a GBV_ILN_227
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|a GBV_ILN_244
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|a GBV_ILN_285
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|a GBV_ILN_294
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|a GBV_ILN_350
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|a AR
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|d 51
|j 2013
|e 11
|b 31
|c 11
|h 831-5
|