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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1021/la403591z
|2 doi
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|a pubmed25n0783.xml
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|a (DE-627)NLM234996471
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|a (NLM)24479874
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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|a Balasubramaniam, Sharavanan
|e verfasserin
|4 aut
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| 245 |
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|a Toward design of magnetic nanoparticle clusters stabilized by biocompatible diblock copolymers for T₂-weighted MRI contrast
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 06.10.2014
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|a Date Revised 02.12.2018
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a We report the fabrication of magnetic particles comprised of clusters of iron oxide nanoparticles, 7.4 nm mean diameter, stabilized by a biocompatible, amphiphilic diblock copolymer, poly(ethylene oxide-b-D,L-lactide). Particles with quantitative incorporation of up to 40 wt % iron oxide and hydrodynamic sizes in the range of 80-170 nm were prepared. The particles consist of hydrophobically modified iron oxide nanoparticles within the core-forming polylactide block with the poly(ethylene oxide) forming a corona to afford aqueous dispersibility. The transverse relaxivities (r2) increased with average particle size and exceeded 200 s(-1) mM Fe(-1) at 1.4 T and 37 °C for iron oxide loadings above 30 wt %. These experimental relaxivities typically agreed to within 15% with the values predicted using analytical models of transverse relaxivity and cluster (particle core) size distributions derived from cryo-TEM measurements. Our results show that the theoretical models can be used for the rational design of biocompatible MRI contrast agents with tailored compositions and size distributions
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Research Support, U.S. Gov't, Non-P.H.S.
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7 |
|a Contrast Media
|2 NLM
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| 650 |
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|a Ferric Compounds
|2 NLM
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|a Magnetite Nanoparticles
|2 NLM
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| 650 |
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|a Polyesters
|2 NLM
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| 650 |
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|a ferric oxide
|2 NLM
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| 650 |
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|a 1K09F3G675
|2 NLM
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| 650 |
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|a Polyethylene Glycols
|2 NLM
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| 650 |
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|a 3WJQ0SDW1A
|2 NLM
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| 650 |
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|a poly(lactide)
|2 NLM
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| 650 |
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|a 459TN2L5F5
|2 NLM
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| 700 |
1 |
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|a Kayandan, Sanem
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Lin, Yin-Nian
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Kelly, Deborah F
|e verfasserin
|4 aut
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| 700 |
1 |
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|a House, Michael J
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Woodward, Robert C
|e verfasserin
|4 aut
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| 700 |
1 |
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|a St Pierre, Timothy G
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Riffle, Judy S
|e verfasserin
|4 aut
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| 700 |
1 |
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|a Davis, Richey M
|e verfasserin
|4 aut
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| 773 |
0 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1985
|g 30(2014), 6 vom: 18. Feb., Seite 1580-7
|w (DE-627)NLM098181009
|x 1520-5827
|7 nnas
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| 773 |
1 |
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|g volume:30
|g year:2014
|g number:6
|g day:18
|g month:02
|g pages:1580-7
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| 856 |
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|u http://dx.doi.org/10.1021/la403591z
|3 Volltext
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|d 30
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|e 6
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|c 02
|h 1580-7
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