|
|
|
|
| LEADER |
01000naa a22002652 4500 |
| 001 |
NLM234855061 |
| 003 |
DE-627 |
| 005 |
20231224102146.0 |
| 007 |
cr uuu---uuuuu |
| 008 |
231224s2014 xx |||||o 00| ||eng c |
| 024 |
7 |
|
|a 10.1002/mrc.4048
|2 doi
|
| 028 |
5 |
2 |
|a pubmed24n0782.xml
|
| 035 |
|
|
|a (DE-627)NLM234855061
|
| 035 |
|
|
|a (NLM)24464591
|
| 040 |
|
|
|a DE-627
|b ger
|c DE-627
|e rakwb
|
| 041 |
|
|
|a eng
|
| 100 |
1 |
|
|a Liang, Xianrui
|e verfasserin
|4 aut
|
| 245 |
1 |
4 |
|a The application of quantitative NMR for the facile, rapid and reliable determination of clindamycin phosphate in a conventional tablet formulation
|
| 264 |
|
1 |
|c 2014
|
| 336 |
|
|
|a Text
|b txt
|2 rdacontent
|
| 337 |
|
|
|a ƒaComputermedien
|b c
|2 rdamedia
|
| 338 |
|
|
|a ƒa Online-Ressource
|b cr
|2 rdacarrier
|
| 500 |
|
|
|a Date Completed 23.10.2014
|
| 500 |
|
|
|a Date Revised 20.11.2014
|
| 500 |
|
|
|a published: Print-Electronic
|
| 500 |
|
|
|a Citation Status MEDLINE
|
| 520 |
|
|
|a Copyright © 2014 John Wiley & Sons, Ltd.
|
| 520 |
|
|
|a Spectroscopic tools such as NMR can be applied to the quantitative analysis of active pharmaceutical ingredients with relative ease and accuracy. Here, we demonstrate the quantification of clindamycin phosphate (CLP) in a conventional tablet formulation, performed using potassium hydrogen phthalate (KHP) as the internal standard and deuterium oxide (D2O) as the NMR solvent. The methyl protons signal of CLP at 0.72 ppm (triplet) relative to the signal of KHP at 7.37-7.40 ppm (multiplet) was used for quantification purposes using (1)H NMR. This method was shown to be specific and linear (r = 0.9997) within the CLP concentration range from 7.2 to 23.1 mg per 0.5 ml of D2O. The maximum relative standard deviation (RSD) of accuracy and precision was calculated at 0.39% and 0.64%, respectively. The limits of detection (LOD) and quantification were 0.04 and 0.11 mg/ml, respectively. The method was highly stable with a calculated RSD of 0.03%. The robustness of the method was demonstrated by changing four different parameters, and the difference among each parameter was ≤ 0.78%. The findings of this work were in good agreement with previously reported conventional HPLC-based approaches, highlighting its applicability in the determination of other active pharmaceutical ingredients in conventional formulations for quality control purposes
|
| 650 |
|
4 |
|a Journal Article
|
| 650 |
|
4 |
|a 1H NMR
|
| 650 |
|
4 |
|a NMR
|
| 650 |
|
4 |
|a clindamycin phosphate
|
| 650 |
|
4 |
|a drug validation
|
| 650 |
|
4 |
|a quality control
|
| 650 |
|
4 |
|a quantitative NMR
|
| 650 |
|
7 |
|a Tablets
|2 NLM
|
| 650 |
|
7 |
|a Clindamycin
|2 NLM
|
| 650 |
|
7 |
|a 3U02EL437C
|2 NLM
|
| 650 |
|
7 |
|a clindamycin phosphate
|2 NLM
|
| 650 |
|
7 |
|a EH6D7113I8
|2 NLM
|
| 700 |
1 |
|
|a Du, Liping
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Su, Feng
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Parekh, Harendra S
|e verfasserin
|4 aut
|
| 700 |
1 |
|
|a Su, Weike
|e verfasserin
|4 aut
|
| 773 |
0 |
8 |
|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 52(2014), 4 vom: 14. Apr., Seite 178-82
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
|
| 773 |
1 |
8 |
|g volume:52
|g year:2014
|g number:4
|g day:14
|g month:04
|g pages:178-82
|
| 856 |
4 |
0 |
|u http://dx.doi.org/10.1002/mrc.4048
|3 Volltext
|
| 912 |
|
|
|a GBV_USEFLAG_A
|
| 912 |
|
|
|a SYSFLAG_A
|
| 912 |
|
|
|a GBV_NLM
|
| 912 |
|
|
|a GBV_ILN_350
|
| 951 |
|
|
|a AR
|
| 952 |
|
|
|d 52
|j 2014
|e 4
|b 14
|c 04
|h 178-82
|