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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1002/mrc.4047
|2 doi
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|a pubmed24n0782.xml
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|a DE-627
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|c DE-627
|e rakwb
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|a eng
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|a Dal Poggetto, Guilherme
|e verfasserin
|4 aut
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|a 19F DOSY NMR analysis for spin systems with nJFF couplings
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
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|2 rdamedia
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|a ƒa Online-Ressource
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|2 rdacarrier
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|a Date Completed 23.10.2014
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|a Date Revised 07.03.2014
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Copyright © 2014 John Wiley & Sons, Ltd.
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|a NMR is a powerful method for identification and quantification of drug components and contaminations. These problems present themselves as mixtures, and here, one of the most powerful tools is DOSY. DOSY works best when there is no spectral overlap between components, so drugs containing fluorine substituents are well-suited for DOSY analysis as (19)F spectra are typically very sparse. Here, we demonstrate the use of a modified (19)F DOSY experiment (on the basis of the Oneshot sequences) for various fluorinated benzenes. For compounds with significant (n) JFF coupling constants, as is common, the undesirable J-modulation can be efficiently suppressed using the Oneshot45 pulse sequence. This investigation highlights (19)F DOSY as a valuable and robust method for analysis of molecular systems containing fluorine atoms even where there are large fluorine-fluorine couplings
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a 19F
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|a DOSY
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|a Fluorobenzenes
|2 NLM
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|a Fluorine
|2 NLM
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|a 284SYP0193
|2 NLM
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|a Favaro, Denize C
|e verfasserin
|4 aut
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|a Nilsson, Mathias
|e verfasserin
|4 aut
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|a Morris, Gareth A
|e verfasserin
|4 aut
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|a Tormena, Cláudio F
|e verfasserin
|4 aut
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|i Enthalten in
|t Magnetic resonance in chemistry : MRC
|d 1985
|g 52(2014), 4 vom: 24. Apr., Seite 172-7
|w (DE-627)NLM098179667
|x 1097-458X
|7 nnns
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| 773 |
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|g volume:52
|g year:2014
|g number:4
|g day:24
|g month:04
|g pages:172-7
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|u http://dx.doi.org/10.1002/mrc.4047
|3 Volltext
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