Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells

Developmentally regulated GTP-binding protein 2 ameliorates EAE by suppressing the development of TH17 cells

Copyright © 2013 Elsevier Inc. All rights reserved.

Bibliographische Detailangaben
Veröffentlicht in:Clinical immunology (Orlando, Fla.). - 1999. - 150(2014), 2 vom: 01. Feb., Seite 225-35
1. Verfasser: Ko, Myoung Seok (VerfasserIn)
Weitere Verfasser: Kim, Hyo Jeong, Kim, Hong Kyung, Yoon, Nal Ae, Lee, Unn Hwa, Lee, Sang Chul, Chung, Dae Kyun, Lee, Byung Ju, Suh, Jae Hee, Cho, Wha Ja, Park, Jeong Woo
Format: Online-Aufsatz
Sprache:English
Veröffentlicht: 2014
Zugriff auf das übergeordnete Werk:Clinical immunology (Orlando, Fla.)
Schlagworte:Journal Article Research Support, Non-U.S. Gov't DRG2 EAE IL-6 NF-κB PPARγ T(H)17 Co-Repressor Proteins Cytokines mehr... Inflammation Mediators Interleukin-6 NF-kappa B PPAR gamma developmentally regulated GTP-binding protein 149371-72-2 GTP-Binding Proteins EC 3.6.1.-
Beschreibung
Zusammenfassung:Copyright © 2013 Elsevier Inc. All rights reserved.
Developmentally regulated GTP-binding protein 2 (DRG2) represents a novel subclass of GTP-binding proteins. We here report that transgenic overexpression of DRG2 in mice ameliorates experimental autoimmune encephalomyelitis (EAE), a murine model of multiple sclerosis (MS). The protective effect of DRG2 in EAE was mediated by the inhibition of the development of T(H)17 cells. DRG2 enhanced the activity of PPARγ, which led to an inhibition of the nuclear factor kappa B (NF-κB) activity and IL-6 production in antigen presenting cells and an inhibition of the development of T(H)17 cells. Our results demonstrate that DRG2 is an essential modulator of EAE
Beschreibung:Date Completed 08.04.2014
Date Revised 05.02.2014
published: Print-Electronic
Citation Status MEDLINE
ISSN:1521-7035
DOI:10.1016/j.clim.2013.12.004