Poly(ethylene glycol)-modified PAMAM-Fe3O4-doxorubicin triads with the potential for improved therapeutic efficacy : generation-dependent increased drug loading and retention at neutral pH and increased release at acidic pH

Polyamidoamine (PAMAM) dendrimer-coated magnetic nanoparticles are a promising drug-delivery system that can enhance the therapeutic effects of chemotherapy drugs, such as doxorubicin (DOX), with minimized side effects. This work explores the optimization of the potential therapeutic efficiency of P...

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Veröffentlicht in:	Langmuir : the ACS journal of surfaces and colloids. - 1992. - 30(2014), 4 vom: 04. Feb., Seite 1004-11
1. Verfasser:	Nigam, Saumya (VerfasserIn)
Weitere Verfasser:	Chandra, Sudeshna, Newgreen, Donald F, Bahadur, Dhirendra, Chen, Qizhi
Format:	Online-Aufsatz
Sprache:	English
Veröffentlicht:	2014
Zugriff auf das übergeordnete Werk:	Langmuir : the ACS journal of surfaces and colloids
Schlagworte:	Journal Article Research Support, Non-U.S. Gov't Antibiotics, Antineoplastic Dendrimers Drug Carriers Magnetite Nanoparticles PAMAM Starburst Glutamic Acid 3KX376GY7L Polyethylene Glycols mehr... 3WJQ0SDW1A Doxorubicin 80168379AG Ferrosoferric Oxide XM0M87F357