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231224s2014 xx |||||o 00| ||eng c |
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|a 10.1021/la404310p
|2 doi
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|a pubmed24n0782.xml
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|a (NLM)24443819
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|a DE-627
|b ger
|c DE-627
|e rakwb
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| 041 |
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|a eng
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| 100 |
1 |
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|a Russo, Laura
|e verfasserin
|4 aut
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| 245 |
1 |
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|a Thiol-ene mediated neoglycosylation of collagen patches
|b a preliminary study
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|c 2014
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|a Text
|b txt
|2 rdacontent
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|a ƒaComputermedien
|b c
|2 rdamedia
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|a ƒa Online-Ressource
|b cr
|2 rdacarrier
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|a Date Completed 21.10.2014
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|a Date Revised 11.02.2014
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|a published: Print-Electronic
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|a Citation Status MEDLINE
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|a Despite the relevance of carbohydrates as cues in eliciting specific biological responses, the covalent surface modification of collagen-based matrices with small carbohydrate epitopes has been scarcely investigated. We report thereby the development of an efficient procedure for the chemoselective neoglycosylation of collagen matrices (patches) via a thiol-ene approach, between alkene-derived monosaccharides and the thiol-functionalized material surface. Synchrotron radiation-induced X-ray photoelectron spectroscopy (SR-XPS), Fourier transform-infrared (FT-IR), and enzyme-linked lectin assay (ELLA) confirmed the effectiveness of the collagen neoglycosylation. Preliminary biological evaluation in osteoarthritic models is reported. The proposed methodology can be extended to any thiolated surface for the development of smart biomaterials for innovative approaches in regenerative medicine
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|a Journal Article
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|a Research Support, Non-U.S. Gov't
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|a Biocompatible Materials
|2 NLM
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|a Carbohydrates
|2 NLM
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|a Sulfhydryl Compounds
|2 NLM
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|a Collagen
|2 NLM
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| 650 |
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|a 9007-34-5
|2 NLM
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| 700 |
1 |
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|a Battocchio, Chiara
|e verfasserin
|4 aut
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|a Secchi, Valeria
|e verfasserin
|4 aut
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|a Magnano, Elena
|e verfasserin
|4 aut
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|a Nappini, Silvia
|e verfasserin
|4 aut
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|a Taraballi, Francesca
|e verfasserin
|4 aut
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|a Gabrielli, Luca
|e verfasserin
|4 aut
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|a Comelli, Francesca
|e verfasserin
|4 aut
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| 700 |
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|a Papagni, Antonio
|e verfasserin
|4 aut
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| 700 |
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|a Costa, Barbara
|e verfasserin
|4 aut
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| 700 |
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|a Polzonetti, Giovanni
|e verfasserin
|4 aut
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|a Nicotra, Francesco
|e verfasserin
|4 aut
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|a Natalello, Antonino
|e verfasserin
|4 aut
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|a Doglia, Silvia M
|e verfasserin
|4 aut
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| 700 |
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|a Cipolla, Laura
|e verfasserin
|4 aut
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| 773 |
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|i Enthalten in
|t Langmuir : the ACS journal of surfaces and colloids
|d 1999
|g 30(2014), 5 vom: 11. Feb., Seite 1336-42
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|x 1520-5827
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|g volume:30
|g year:2014
|g number:5
|g day:11
|g month:02
|g pages:1336-42
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|u http://dx.doi.org/10.1021/la404310p
|3 Volltext
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